ACE inhibitors Flashcards
MOA?
inhibits conversion of Angiotensin II → blocking aldosterone
What is the ending for ACE inhibitors?
-prils
Examples of ACE inhibitors?
captopril, enalapril, and lisinopril
Indications?
HTN, HF, MI, diabetic nephropathy
Prevents: MI, stroke, and death in patients at high cardiovascular risk
How do they protect the kidneys?
Will help slow the progression of diabetic nephropathy
Route of administration?
PO except Enalapril
Administer with food or no food?
without regards to meals except for captopril and moexipril
What are the effects of aldosterone not being activated?
vasodilation, ↓ blood volume, ↓ cardiac and vascular remodeling, K retention, and fetal injury
Increase in bradykinin results in?
vasodilation, cough, angioedema
Adverse effects?
cough, angioedema, 1st dose hypotension, hyperkalemia, renal failure, fetal injury, and neutropenia (rare)
Why should pts taking ACE inhibitors avoid taking salt substitutes?
they have a lot of K+
How do we monitor for neutropenia?
Watch for signs of infection
Who should not be given this medication?
pregnant, salt or volume depletion, renal impairment, and K retention issues
T/F. Captopril should be taken with meals?
False; at least 1hr before meals
Drug interactions?
diuretics, antihypertensive, drugs that ↑ K+, Lithium, and NSAIDS
