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PHARM > Antitussives (respiratory) > Flashcards

Antitussives (respiratory) Flashcards

1
Q

What are antitussive opioid options?

A

Codeine and hydrocodone

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2
Q

MOA of codeine?

A

suppresses cough through its action on the CNS to increase the cough threshold

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3
Q

Therapeutic use for codeine?

A

off-label cough suppression

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4
Q

Adverse effects of codeine?

A

RESPIRATORY DEPRESSION, dizziness, lightheadedness, drowsiness, risk for abuse

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5
Q

What is the prototype for non-opioid antitussives?

A

Dextromethorphan (Delsym)

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6
Q

Therapeutic use of Dextromethorphan?

A

cough suppression; can reduce pain when prescribed with an opioid

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7
Q

MOA of Dextromethorphan?

A

Suppresses the cough center in the medulla

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8
Q

Adverse effects of DextRomethorphaN?

A

dizziness, sedation, rash, nausea

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9
Q

Contraindications for Dextromethorphan?

A

concurrent or within 14 days of MAOI use, SSRI use, hypersensitivity

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10
Q

Precautions with use of Dextromethorphan?

A
  • cough that last more than 1 week or is accompanied by a fever, rash, or HA can be a sign of a serious condition and PCP should be consulted.
  • Hx of drug abuse or drug seeking behavior.
  • diabetes (some drugs contain sucrose)*
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11
Q

Onset of action and route for Dextromethorphan?

A

onset: 15-30 minutes
route: PO- liquid, lozenges, and syrup

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12
Q

What is the prototype for Expectorants?

A

Guaifenesin (Robitussin, Mucinex)

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13
Q

Therapeutic use of Guaifenesin?

A

expectorant; to facilitate removal of phlegm during a cough

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14
Q

MOA of Guaifenesin?

A

increases volume and decreases viscosity of respiratory tract secretions

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15
Q

Adverse effects of GuaifeNesin?

A

rash, HA, N/V, dizziness

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16
Q

Guaifenesin precautions?

A
  • cough lasting 1 week or accompanied by fever, rash, or HA should consult PCP.
  • diabetes (some formulas contain sucrose)
  • children < 2
17
Q

Onset of action and route of Guaifenesin?

A

Onset: 30min
route: PO, PO-ER

PHARM (35 decks)

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