Adrenal cortex disorder Flashcards
1
Q
Prototype for adrenal hormone replacement?
A
Hydrocortisone
2
Q
MOA of a Hydrocortisone?
A
glucocorticoid with mineralocorticoid actions
3
Q
Adverse effects of Hydrocortisone?
A
chronic high dose therapy can lead to adrenal suppression and development of Cushing’s syndrome
4
Q
When should glucocorticoid doses be increased?
A
At time of stress. Failure to do so may be fatal.
5
Q
How is Fludrocortisone different than hydrocortisone?
A
it is a potent mineralocorticoid
6
Q
Therapeutic use of Fludrocortisone?
A
primary adrenal insufficiency
7
Q
Adverse effects of Fludrocortisone?
A
salt and water retention leading to increased blood volume, HTN, edema, and cardiac enlargement
8
Q
What should we monitor for with use of Fludrocortisone?
A
weight gain, elevated BP, and hypokalemia
