GU Flashcards
Are anticholinergics muscarinic agonists or antagonists?
antagonists
Example of muscarinic antagonist for reversal of Bethanechol toxicity?
Atropine
MOA of Atropine?
Will help the heart speed up by blocking the cholinergic receptors.
Prototype for muscarinic agonist for urinary retention?
Bethanechol (Urecholine)
Therapeutic use of Bethanechol?
urinary retention
MOA of Bethanechol?
Stimulates the release of Ach which activates the PNS
What are the adverse effects of Bethanechol?
Hypotension, bradycardia, increased tone and motility of GI, exacerbation of asthma, dysrhythmias in patients with hyperthyroidism.
Sx of Bethanechol toxicity?
profuse salivation, lacrimation, visual disturbances, bronchospasms, diarrhea, bradycardia, hypotension, cardiovascular collapse.
What is the tx for Bethanechol toxicity?
Atropine and supportive therapy
How do we evaluate the effectiveness of Bethanechol?
monitor I/Os
Contraindications for Bethanechol?
PUD, urinary or GI obstruction, coronary insufficiency, hypotension, asthma, and hyperthyroidism
How is Bethanechol taken in regards to meals?
PO 1 hour AC or 2 hrs PC to reduce gastric upset
What are the 4 major symptoms of an overactive bladder?
urgency, frequency, nocturia, and urge incontinence.
Prototype for anticholinergic drug for overactive bladder?
Oxybutynin (Ditropan XL, Oxytrol)
Therapeutic use for Oxybutynin?
overactive bladder
Adverse effects of of Oxybutynin?
anticholinergic effects: Xerostomia (dry mouth), blurred vision, photophobia, constipation, hyperthermia
Symptoms of Oxybutynin overdose?
dry mouth, blurred vision, photophobia, hyperthermia, hallucinations, and delirium; the skin becomes hot, dry, and flushed.
What is the reversal agent for Oxybutynin toxicity?
Physostigmine
Available routes for Oxybutynin?
transdermal patch and topical gel
Oxybutynin is contraindicated in who?
patients with glaucoma, intestinal atony, urinary tract obstruction, and tachycardia.
Name 2 examples of PDE5 inhibitors?
Viagra and Cialis