Glucocorticoids in Nonendocrine disorders

Question 1

When is the best time to take steroids?

Answer 1

Administering before 9AM

Question 2

What drug interactions should we look out for?

Answer 2

Diuretics, NSAIDs, insulin, vaccines, Digoxin

Question 3

Contraindications for glucocorticoids?

Answer 3

systemic fungal infections and live virus vaccines

Question 4

What other groups should we be cautious about giving steroids to?

Answer 4

pediatrics, pregnant or breastfeeding, HF, GI issues, DM, osteoporosis, and current resistant infection

Question 5

MOA of glucocorticoids?

Answer 5

anti-inflammatory and immunosuppressive

Question 6

What is the suffix for steroids?

Answer 6

-sone

Question 7

What are the adverse affects?

4S’s (Swollen, sepsis, sugar, skinny, sight)

Answer 7

adrenal insufficiency, osteoporosis, infection, high glucose levels, myopathy, iatrogenic cushing’s syndrome, Na+ and water retention, K+ loss, growth retardation, psychological disturbances, cataracts and glaucoma, and peptic ulcer disease

Question 8

How do we prevent adrenal insufficiency?

Answer 8

Tapering down

Question 9

What are the sx of Cushing’s syndrome?

Answer 9

hyperglycemia, glycosuria, fluid and electrolyte disturbances, osteoporosis, msl weakness, cutaneous striations, lowered resistance to infection, redistribution of fat → moon face, buffalo hump