Anti-platelets

Question 1

Why are glycoprotein IIb/IIa receptor antagonists considered “super aspirins”?

Answer 1

inhibit the final step in aggregation; prevent aggregation stimulated by all factors.

Question 2

Uses?

Answer 2

prevent ischemic events in patients with ACS or undergoing Percutaneous coronary intervention (PCI)

Question 3

Prototypes for anti-platelets used in the hospital?

Answer 3

Abciximab (ReoPro) and Eptifibatide (Integrilin)

Question 4

Suffix ending for monoclonal antibodies?

Answer 4

-mab

Question 5

MOA of Abciximab?

Answer 5

Binds near the receptors to block fibrinogen from binding.

Question 6

How long do effects last after giving Abicixmab?

Answer 6

24-48 hours after stopping the infusion

Question 7

MOA of Integrilin?

Answer 7

Small peptide that inhibits platelet aggregation by binding to GP IIb/IIa

Question 8

How much ASA should you take for the prevention of arterial thrombosis? chronic management?

Answer 8

prevention: 325mg or less

chronic management: 81mg or less

Question 9

Which anti-platelet can be taken at home after having stents placed?

Answer 9

Clopidogrel

Question 10

MOA of Clopidogrel?

Answer 10

irreversibly blocks receptors for ADP (7-10 days)

Question 11

Clopidogrel uses?

Answer 11

prevent stenosis of coronary stents and for secondary prevention of MI, ischemic stroke, and other vascular events.

Question 12

Clopidogrel adverse effects?

Answer 12

TTP

Question 13

Contraindications and precautions for Clopidogrel?

Answer 13

Contraindications: active pathological bleeding, including ICH and bleeding ulcers.

cautions: when taking proton pump inhibitors (PPI)

Question 14

How does PPI use effect the effectiveness of Clopidogrel?

Answer 14

Will not work as well

Question 15

How should Clopidogrel be taken?

Answer 15

1/day with or without food

Question 16

Why should you avoid drugs that promote bleeding when taking Clopidogrel?

Answer 16

D/t increased bleeding risk with use

Question 17

Why should you avoid cytochrome P450 (CYP2C19) inhibitors when taking Clopidogrel?

Answer 17

Decreased effectiveness d/t poor metabolism

Question 18

Lifespan of platelets?

Answer 18

7-10 days

Question 19

MOA of ASA?

Answer 19

irreversibly inhibits cyclooxygenase therefore blocking synthesis of TXA.