H. pylori Diagnostic Testing Module (Quiz)

Question 1

what are the tests for H. pylori

which are the active tests and document eradication

which tests are invasive

Answer 1

• serology
• urea breath test (active)
• stool antigen test (active)
• rapid urease test (active and invasive)
• histology (biopsy) (active and invasive)

Question 2

H. pylori serology test detects what

negative of this

Answer 2

• antibodies against H. pylori

- antibodies can still be detected after treatmentwhi

Question 3

which test does not require active infection in order to be positive

Answer 3

• serology

Question 4

which test is not affected by the concurrent use of proton pump inhibitors

Answer 4

• serology

Question 5

what does H. pylori produce

how

Answer 5

• urease

- converts urea to ammonia and CO2

Question 6

how does urease breath test work

Answer 6

• patient given urea tagged with radioactive carbon

- H. pylori will convert that urea into CO2 which the patient can breathe out

Question 7

problem of active H. pylori tests

Answer 7

• antibiotics or proton pump inhibitors can decrease sensitivity for detecting active infection

Question 8

how does stool antigen test work

Answer 8

• detects bacterial antigen from H. pylori that are present in the stool

Question 9

why is the rapid urease test invasive

Answer 9

• requires upper endoscopy

Question 10

how rapid urease test works

Answer 10

• pH increases as urea is hydrolyzed to ammonia

- gel changes from yellow to pink

Question 11

another name for rapid ureas test

Answer 11

• CLOtest

Question 12

what is the gold standard for H. pylori diagnosis

Answer 12

• gastric biopsy and histology