Gyn Path II

Question 1

Endometrial hyperplasia is diffuse proliferation of the endometrium due to _____

Answer 1

unopposed estrogen

Question 2

__ and anything that causes it are protective against Endometrial hyperplasia

Answer 2

Progesterone

Question 3

Endometrial hyperplasia histologically see ___ gland to stroma ratio and __ activity

Answer 3

increased; mitotic

Question 4

Endometrial hyperplasia is classified as with or without ___ and __ or ___ based on glands

Answer 4

atypia; simple; complex

Question 5

Carcinoma seen with complex atypical histology for Endometrial hyperplasia is the same whether you wait or do a ____ right away

Answer 5

hysterectomy

Question 6

The two glandular patterns seen in endometrial carcinoma are ___ and ____. These glands can also ____ surrounding stroma

Answer 6

papillary and cribriform; invade

Question 7

Type I Endometrial Carcinoma is dependent on ____

Answer 7

estrogen

Question 8

Type II Endometrial Carcinoma is associated with a __ mutation and is ___ aggressive than type I

Answer 8

p53; more

Question 9

Type I Endometrial Carcinoma precursor is ____ ___ while type II is ___ ___

Answer 9

atypical hyperplasia; intraepithelial carcinoma

Question 10

Cervical cancer is strongly associated with __, specifically types __ and __

Answer 10

HPV; 16;18

Question 11

HPV ___ is necessary for progression to cancer

Answer 11

persistence