Breast Path Flashcards
__ changes in the breast is a risk factor for breast cancer
fibrocystic
In Situ carcinomas do not ____ and they proliferate where?
spread; in their original location
DCIS is a _ __ precursor of ___ ___
non-obligate; invasive carcinomas
DCIS show ___ ___ on path
calcified necrosis
Clinically, DCIS are __ (feature) and ___ (treatment)
benign; treatable
LCIS cells proliferate and destroy the original
lumen
LCIS are only seen __ on imaging
incidentally
LCIS frequently has __ __ cells on path
signet ring
LCIS treatment is ___ and __ (style) or ___ (drug) rather than mastectomy
watch and wait; tamoxifen
DCIS can be seen on a __ which is the most common way they’re found
mammogram
__ disease of the ___ signifies an underlying breast cancer which has spread from the ducts to the skin of the nipple. Can be __ __ or __. Presents with a __ of the nipple
Paget; nipple; in-situ; invasive; crusting
__ breast carcinoma presents with reddening of the breast and is a serious form of cancer. There are no __ cells but cancer is seen in the __ lymphatics
Inflammatory; inflammatory; dermal
What does the TMN staging shorthand stand for?
Tumor size, metastasis, lymph nodes
Predictive markers look for what two receptors and why?
estrogen and progesterone, to predict response to anti-hormonal treatment
___ protein overexpression predicts response to __ (drug)
Her-2; trastuzumab
Oncotype DX tests work in patients with what 3 characteristics?
ER-positive, node-negative, and can withstand 5 years of tamoxifen
Oncotype DX low risk patients get no __; high risk groups get ___; the middle is unclear
chemo
__ syndrome is a risk factor for male breast cancer: so is the __ gene
Klinefelter (xxy); BRCA2
Male breast cancer is ___ only
ductal
