ED Flashcards
Stress causes a ___ in testosterone in males
decrease
The preoptic, anterior and ventromedial nuclei of the hypothalamus are important for
male fertility
GnRH is made in the
preoptic anterior hypothalamus
Kallman syndrome (no GnRH production) patients have an altered sense of __ because GnRH neurons migrate from the ___ to the hypothalamus
smell; nose
Continuous release of GnRH causes a ___ of GnRH receptors because of the loss of the ___ and only having peaks
decrease; troughs
LH has a ___ half life and acts on LH receptors on __ cells
short; leydig
FSH has a __ half life and acts on FSH receptors on __ cells
long; sertoli
Testosterone is released from the __ cells and provides negative feedback to the ___ and the ___
leydig; hypothalamus; anterior pituitary
Estradiol is converted from testosterone by ___ and has a ___ negative feedback effect than testosterone
aromatase; stronger
Inhibin B acts on the __ to limit ___ secretion
anterior pituitary; FSH
Testosterone has a direct effect on (LH or FSH) secretion
LH
Exogenous testosterone ____ endogenous testosterone through ___ and __ sperm count through __
decreases; LH; decreases; FSH
Puberty causes __ surges of LH and FSH and __ the HPA axis sensitivity to steroids
nocturnal; resets
Testosterone production occurs in the ___ compartment
peritubular
What is the rate limiting step in the synthesis of testosterone and what protein is it done by?
The transport of cholesterol along the mitochondrial membrane; SAR
Only __% of testosterone is actually bioavailable
40
The major sign of hypogonadism in males is
testicular atrophy
Primary hypogonadism is a defect of the ___ themselves with very high __ and __ levels
testicles; FSH and LH
Secondary hypogonadism is a ___ defect
central
__ are an acquired form of hypogonadism due to hyperthermia of the scrotum
Varicoceles
The Hypothalamus has the __ which recognizes a sexual partner
MPOA
The PVN and the PGN do what to the erection
stimulate and inhibit respectively
The locus coeruleus is the __ center
integration
The sympathetics arise from T _ - __ and the PS arise from S_-_
10-12; 2-4
Projectile ejaculation is a skeletal muscle function done by the __ nerve
pudendal
ED drugs work on __ and require ___ to work
PDE-5; stimulation
ED often precedes __ disease
heart
Sexulation stimulation involves the __ pathway and the enzyme which non-sexual erection involves __
NO; PDE-; prostaglandins
