ED

Question 1

Stress causes a ___ in testosterone in males

Answer 1

decrease

Question 2

The preoptic, anterior and ventromedial nuclei of the hypothalamus are important for

Answer 2

male fertility

Question 3

GnRH is made in the

Answer 3

preoptic anterior hypothalamus

Question 4

Kallman syndrome (no GnRH production) patients have an altered sense of __ because GnRH neurons migrate from the ___ to the hypothalamus

Answer 4

smell; nose

Question 5

Continuous release of GnRH causes a ___ of GnRH receptors because of the loss of the ___ and only having peaks

Answer 5

decrease; troughs

Question 6

LH has a ___ half life and acts on LH receptors on __ cells

Answer 6

short; leydig

Question 7

FSH has a __ half life and acts on FSH receptors on __ cells

Answer 7

long; sertoli

Question 8

Testosterone is released from the __ cells and provides negative feedback to the ___ and the ___

Answer 8

leydig; hypothalamus; anterior pituitary

Question 9

Estradiol is converted from testosterone by ___ and has a ___ negative feedback effect than testosterone

Answer 9

aromatase; stronger

Question 10

Inhibin B acts on the __ to limit ___ secretion

Answer 10

anterior pituitary; FSH

Question 11

Testosterone has a direct effect on (LH or FSH) secretion

Answer 11

LH

Question 12

Exogenous testosterone ____ endogenous testosterone through ___ and __ sperm count through __

Answer 12

decreases; LH; decreases; FSH

Question 13

Puberty causes __ surges of LH and FSH and __ the HPA axis sensitivity to steroids

Answer 13

nocturnal; resets

Question 14

Testosterone production occurs in the ___ compartment

Answer 14

peritubular

Question 15

What is the rate limiting step in the synthesis of testosterone and what protein is it done by?

Answer 15

The transport of cholesterol along the mitochondrial membrane; SAR

Question 16

Only __% of testosterone is actually bioavailable

Answer 16

40

Question 17

The major sign of hypogonadism in males is

Answer 17

testicular atrophy

Question 18

Primary hypogonadism is a defect of the ___ themselves with very high __ and __ levels

Answer 18

testicles; FSH and LH

Question 19

Secondary hypogonadism is a ___ defect

Answer 19

central

Question 20

__ are an acquired form of hypogonadism due to hyperthermia of the scrotum

Answer 20

Varicoceles

Question 21

The Hypothalamus has the __ which recognizes a sexual partner

Answer 21

MPOA

Question 22

The PVN and the PGN do what to the erection

Answer 22

stimulate and inhibit respectively

Question 23

The locus coeruleus is the __ center

Answer 23

integration

Question 24

The sympathetics arise from T _ - __ and the PS arise from S_-_

Answer 24

10-12; 2-4

Question 25

Projectile ejaculation is a skeletal muscle function done by the __ nerve

Answer 25

pudendal

Question 26

ED drugs work on __ and require ___ to work

Answer 26

PDE-5; stimulation

Question 27

ED often precedes __ disease

Answer 27

heart

Question 28

Sexulation stimulation involves the __ pathway and the enzyme which non-sexual erection involves __

Answer 28

NO; PDE-; prostaglandins