General Embryology 1/12/17 Flashcards
What is embryology?
-Study of prenatal development
When does prenatal development occur?
Start with pregnancy until birth
What two periods of prenatal development occur during the first trimester?
- Perimplantation
- Embryonic
What period constitutes the last two trimesters?
-Fetal period
Each craniofacial structure has a ____ the earliest indication of a tissue or an organ during prenatal development.
-Primordium (fore runner for structure)
From the zygote what does mitosis lead to the formation of?
-blastocyst
What does the blastocysts contain?
-a fluid filled vesicle that implants in the uterine wall
The blastocyst will then give way to a disc and begin to differentiate into what?
3 distinct germ layers
What are three ways that growth factors can work?
- Autocrine
- Paracrine
- Endocrine
What are three changes that can be induced by growth factors?
- Proliferation
- Differentiation
- Apoptosis
What is a critical growth factor in craniofacial development?
-Bone morphogenic protein (BMP)
At gastrulation what happens with BMP?
-Switches between epidermal vs neural fate
What is a Negative regulator of myogenesis? (makes bone instead of muscle)
BMP
What type of genes code for transcription factors that make cells pattern into one tissue organ type or another?
-Homeobox genes
What type of genes are involved in bodily segmentation during embryonic development?
-Homeobox genes
What type of genes help regulate which end is going to be which?
-Homeobox genes
What cell adhesion molecules are calcium dependent?
-Cadherins
What cell adhesion molecules are calcium independent?
-CAM
What molecules are responsible for specific cell aggregation and sorting?
-Cell adhesion molecules
Nuerectoderm progenitors express what adhesion molecule?
-N-CAM
Skin ectoderm progenitors express what adhesion molecule?
-L-CAM
What is the first period of embryological development?
-Perimplantation period
What does the perimplantation period occur?
-During the first week after conception
To form a blastocyst what must occur?
-Cell division (mitosis)
After fertilization, the zygote undergoes mitosis, or individual cell divsion or ______?
Cleavage
After the initial cleavage of the zygote what is the solid ball of cells known as?
-Morula
When the blastocyst stops and implants in the thickened uterine wall or endometrium it is known as what process?
-Implantation