3/16/17 Salivary gland secretion BAKER TEST #3 Flashcards
What cells are responsible for saliva secretion?
-Acinar cells
What is the area of the salivary gland that faces the blood?
-Basolateral
What is the area of the salivary gland that faces the lumen?
-Apical
What cells involved in salivary glands have a central nucleus?
-Serous cells
What do serous cells produce?
-Amylase
What type of cells is the parotid gland mostly made of?
-Serous cells
If you have mixed parotid and mucous cells but mostly serous what salivary gland do you have?
-Submandibular gland
What do minor salivary glands produce?
-Mucin
What type of cells are mostly in the sublingual gland?
-mucous cells
What type of cell are richly found in the intercalated duct (cubical cells) regions of salivary glands
Progenitor cells
What is the main important thing Dr. Baker wants us to know about the striated duct region?
-It is Rich in mitochondria
What are the two stages in the saliva secretion model?
- Chloride-mediated secretion (stage 1)
- Bicarbonate-mediated secretion (stage 1)
- NaCl reabsorption K+ secretion (stage 2)
Sympathetics in salivary production produce what?
Protein
What neurotransmitter does acetylcholine bind to for a receptor?
-M3R
When Ach bind the M3R receptor what type of G protein is involved?
-Gq
When Ach binds the M3R receptor and involves the Gq G protein what enzyme is involved next?
-PLC
When Ach binds the M3R receptor and involves the Gq G protein using the PLC enzyme, it will use what second messenger?
-IP3
When you have Norepinephrine as a neurotransmitter what receptor will it bind?
-Adrenergic
When you have norepinephrine binding an adrenergic receptor what G protein does it involve?
-Gs
When you have norepinephrine binding an adrenergic receptor using Gs as the G protein what enzyme does it use next?
-AC
When you have norepinephrine binding an adrenergic receptor using Gs as the G protein and the AC enzyme what second messenger does it use?
-cAMP
What does the IP3 lead to?
-increase of intracellular Ca2+ opening the Cl- channel (ion channel activation) leading to fluid & electrolyte secretion
In protein secretion there is a pathway that transports cell membrane proteins in vesicles to cell membrane and does not require neurotransmitters, what pathway is this?
-Constitutive pathway
In protein secretion there is a pathway that is the transport of secretory proteins in vesicles that bud from golgi minimal agonist concentration, what pathway is this?
-Constitutive-like pathway
