3/16/17 Salivary gland secretion BAKER TEST #3 Flashcards

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1
Q

What cells are responsible for saliva secretion?

A

-Acinar cells

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2
Q

What is the area of the salivary gland that faces the blood?

A

-Basolateral

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3
Q

What is the area of the salivary gland that faces the lumen?

A

-Apical

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4
Q

What cells involved in salivary glands have a central nucleus?

A

-Serous cells

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5
Q

What do serous cells produce?

A

-Amylase

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6
Q

What type of cells is the parotid gland mostly made of?

A

-Serous cells

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7
Q

If you have mixed parotid and mucous cells but mostly serous what salivary gland do you have?

A

-Submandibular gland

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8
Q

What do minor salivary glands produce?

A

-Mucin

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9
Q

What type of cells are mostly in the sublingual gland?

A

-mucous cells

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10
Q

What type of cell are richly found in the intercalated duct (cubical cells) regions of salivary glands

A

Progenitor cells

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11
Q

What is the main important thing Dr. Baker wants us to know about the striated duct region?

A

-It is Rich in mitochondria

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12
Q

What are the two stages in the saliva secretion model?

A
  • Chloride-mediated secretion (stage 1)
  • Bicarbonate-mediated secretion (stage 1)
  • NaCl reabsorption K+ secretion (stage 2)
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13
Q

Sympathetics in salivary production produce what?

A

Protein

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14
Q

What neurotransmitter does acetylcholine bind to for a receptor?

A

-M3R

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15
Q

When Ach bind the M3R receptor what type of G protein is involved?

A

-Gq

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16
Q

When Ach binds the M3R receptor and involves the Gq G protein what enzyme is involved next?

A

-PLC

17
Q

When Ach binds the M3R receptor and involves the Gq G protein using the PLC enzyme, it will use what second messenger?

A

-IP3

18
Q

When you have Norepinephrine as a neurotransmitter what receptor will it bind?

A

-Adrenergic

19
Q

When you have norepinephrine binding an adrenergic receptor what G protein does it involve?

A

-Gs

20
Q

When you have norepinephrine binding an adrenergic receptor using Gs as the G protein what enzyme does it use next?

A

-AC

21
Q

When you have norepinephrine binding an adrenergic receptor using Gs as the G protein and the AC enzyme what second messenger does it use?

A

-cAMP

22
Q

What does the IP3 lead to?

A

-increase of intracellular Ca2+ opening the Cl- channel (ion channel activation) leading to fluid & electrolyte secretion

23
Q

In protein secretion there is a pathway that transports cell membrane proteins in vesicles to cell membrane and does not require neurotransmitters, what pathway is this?

A

-Constitutive pathway

24
Q

In protein secretion there is a pathway that is the transport of secretory proteins in vesicles that bud from golgi minimal agonist concentration, what pathway is this?

A

-Constitutive-like pathway

25
Q

If patients damage the Cftr channel (cystic fibrosis) what is their saliva like?

A

-Salty

26
Q

In protein secretion there is a pathway that does the rapid release of granules that has fusion to the luminal cell surface and has high doses of neurotransmitter, which pathway is this?

A

-Major regulated pathways

27
Q

In protein secretion there is a pathway that has slow release of granules from vesicles that release from maturing secretory proteins with low doses of neurotransmitter, Human common salivary protein 1 is an example, what pathway is this?

A

-Minor regulated pathways

28
Q

What is the pH of saliva?

A

-near 7

29
Q

What are three conditions that can affect salivary function?

A
  • Developmental abnormalities
  • Autoimmunity
  • Treatment secondary effects
30
Q

Protein secretion occurs as a complete fusion of what at the apical membrane?

A

-Secretory granules

31
Q

Basolateral transporters concentrate what above its electrochemical gradient?

A

-Chloride