4/6/17 Regeneration and Repair TEST #4

Question 1

When thinking of regeneration and repair, which is when you have the complete restoration of tissue architecture and function?

Answer 1

-Regeneration

Question 2

When thinking of regeneration and repair, which is the restoration of function but having altered architecture such as a scar?

Answer 2

-Repair

Question 3

What are the four phases of tissue repair?

Answer 3

• Hemostasis
• Inflammatory
• Reparative phase
• Wound contraction and scarring (not always)

Question 4

What happens in the reparative phase?

Answer 4

-Migration of cells, and formation of granulation tissue

Question 5

What occurs in the hemostasis phase of repair?

Answer 5

-Clot formation

Question 6

What occurs during the inflammatory phase of repair?

Answer 6

• Infiltration of immune cells

- Initiation of repair

Question 7

What is the primary goal of hemostasis?

Answer 7

-Stop bleeding

Question 8

What is the secondary goal of hemostasis?

Answer 8

-Initiation of healing

Question 9

What does the disruption of platelets lead to?

Answer 9

-Coagulation cascade

Question 10

Define hemostasis?

Answer 10

-Transition of blood from a liquid to a fibrillar gel

Question 11

What occurs during primary hemostasis?

Answer 11

-Vascular spasm (constriction) and the initial platelet plug is formed in a damaged blood vessel

Question 12

Primary hemostasis is initiated by exposure of collagen in subendothelium to circulating what?

Answer 12

-Von Willebrand Factor

Question 13

von Willebrand Factors causes what to occur by interacting with platelet surface proteins?

Answer 13

Platelet aggregration

Question 14

If you are missing von Willbrand factor what other things can platelets bind to, to form a clot?

Answer 14

-Collagen via GPVI, and a2B1

Question 15

In secondary hemostasis does the intrinsic or extrinsic pathway use Factor VII and tissue factor interaction that initiate the cascade?

Answer 15

-Extrinsic

Question 16

Why is it called the extrinsic secondary hemostasis?

Answer 16

• It requires tissue factors that is not normally found in the blood

Question 17

In secondary hemostasis does the intrinsic or extrinsic pathway happen from the damaged endothelium?

Answer 17

-Intrinsic

Question 18

Why is it called the intrinsic secondary hemostasis?

Answer 18

-It involves factors found in the blood

Question 19

The main point of the entire coagulation pathway is the conversion of prothrombin into what?

Answer 19

-Thrombin

Question 20

When prothrombin is converted into thrombin, it in turn converts soluble fibrinogen into what?

Answer 20

-Insoluble fibrin

Question 21

What factor in that coagulation cascade can cause Hemophilia A?

Answer 21

-Factor VIII

Question 22

What does tissue injury and leakage of plasma proteins attract to the site?

Answer 22

• Macrophages

- Lymphocytes

Question 23

T/F In epithelial cell migration during the repair phase allows for the formation of new basal lamina

Answer 23

True

Question 24

What do specialized fibroblasts do in wound contraction?

Answer 24

-Have increased actinmyosin

Question 25

Initial collagen deposition in wound contraction is done by what cell?

Answer 25

-Fibroblasts

Question 26

What is the pocket in periodontal diseased formed from?

Answer 26

-Apical migration of junctional epithelium

Question 27

What can arrest the spread of infection into the periodontal tissues?

Answer 27

-Fibrosis

Question 28

What does bacterially induced inflammation at gingival margins cause?

Answer 28

-Destruction of connective tissues

Question 29

If the source of inflammation is removed in periodontal disease what might the formation of a fibrin clot stimulate?

Answer 29

-Reattachment of connective tissues

Question 30

T/F Periodontal disease involves the alveolar bone and you have a much less chance of successful repair

Answer 30

True

Question 31

If you have the infection removed in gingivitis will it repair?

Answer 31

Yes

Question 32

What are the three zones of Dental caries?

Answer 32

• Surface and body
• Dark zone
• Translucent zone

Question 33

What is it known as when the dentin forms between the surviving dentin and restorative material?

Answer 33

-Dentin bridge

Question 34

What are the three key components in tissue engineering?

Answer 34

• Cell source
• Material
• Bioactive component