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Oral Biology 2020 > 2/2/17 Tooth Development Dr. DSouza TEST 2 > Flashcards

2/2/17 Tooth Development Dr. DSouza TEST 2 Flashcards

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1
Q

If you have a 3rd layer of teeth what is that called?

A

-Cleidocranial Dysplasia

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2
Q

If you have no teeth develop what is that called?

A

-Tooth Agenesis

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3
Q

What interactions guide organogenesis?

A

-Epithelial (ectodermal)-mesenchymal

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4
Q

What type of interactions dictate morphogenesis?

A

-Cell-Matrix

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5
Q

What does the cranial neural crest give rise to?

A
  • Ganglia and nerves
  • Adrenal medulla
  • Ectomesenchyme of bones and teeth
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6
Q

When do the cranial neural crest cells migrate?

A

-37 days in utero

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7
Q

What are the primary epithelial bands?

A

-Future ridges of the maxillary and mandibular teeth

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8
Q

What are the thickenings in the primary epithelial bands that become the future teeth called?

A

-Dental Lamina

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9
Q

What are the six stages of crown development?

A
  • Initiation
  • Bud stage
  • Cap stage
  • Bell stage
  • Apposition stage
  • Maturation stage
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10
Q

What occurs in the initiation stage?

A

-Induction

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11
Q

What occurs in the bud stage?

A

-Proliferation

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12
Q

What occurs in the Cap stage?

A
  • Proliferation
  • Differentiation
  • Morphogenesis
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13
Q

What occurs in the Bell stage?

A
  • Proliferation
  • Differentiation
  • Morphogenesis
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14
Q

What occurs in the Apposition stage?

A

-Induction and proliferation

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15
Q

What occurs at the maturation stage?

A

-Maturation

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16
Q

What stage is the shape of the tooth developing?

A

-Cap and Early bell

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17
Q

When the Dental lamina proliferates what does it give rise to?

A

-Tooth bud

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18
Q

In the primary dentition how many buds will you have in each dental lamina?

A

-10

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19
Q

What is each bud a precursor for?

A

-Enamel organ

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20
Q

Define induction in the initiation stage.

A

-THe process whereby one tissue changes the development of surrounding tissues

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21
Q

In tooth development Lef-1 stimulates the pre-dental ectoderm to produce what?

A

-Fgf-8

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22
Q

In tooth development what stimulates the pre-dental ectoderm to produce Fgf-8?

A

-Lef-1

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23
Q

What does Fgf-8 induce the underlying mesenchyme to express?

A
  • Pax-9

- Msx-1

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24
Q

What does BMP-2 and BMP-4 inhibit?

A

-Fgf-8

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25
Q

When the mesenchymal cells pack tightly together by the tooth bud what are the mesenchymal called?

A

-Dental papilla

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26
Q

In the Cap stage what causes the cap to form?

A

-Unequal proliferation of bud cells

27
Q

The Ectomesenchyme cells condense around the developing cap ultimately becoming what?

A
  • Dental papilla

- Dental sac

28
Q

What three things make up the Tooth germ?

A
  • Enamel organ
  • Dental papilla
  • Dental sac
29
Q

What forms on the lingual side of the dental lamina?

A

-Successional dental lamina

30
Q

What will the successional dental lamina give rise to?

A

-Enamel organs of the permanent teeth

31
Q

T/F

The enamel niche is an artifact and not a real structure of the enamel organ

A

True

32
Q

What influences the shape of the tooth?

A

-Mesenchyme

33
Q

What do the enamel knots ultimately become?

A

-Cusps

34
Q

What four distinct layers from from the enamel organ in the Bell stage?

A
  • Outer enamel epithelium
  • Stellate reticulum
  • Stratum intermedium
  • Inner enamel epithelium
35
Q

What is the cervical loop in the bell stage?

A

-Junction of the Outer enamel epithelium and Inner enamel epithelium

36
Q

What do the dental papilla cells continue to proliferate into?

A
  • Outer dental papilla cells

- Inner dental papilla cells

37
Q

What does the dental sac proliferate into eventually?

A

-Periodontal tissues

38
Q

What is the purpose of the outer enamel epithelium?

A

-Protective barrier for enamel organ

39
Q

What is the purpose of the stellate reticulum?

A

-Supports enamel production

40
Q

What is the purpose of the stratum intermedium?

A

-Supports enamel mineralization (alkaline phosphatase)

41
Q

What is the purpose of the inner enamel epithelium?

A

-Differentiate into ameloblasts

42
Q

What stage in crown development is the stage during which organic matrix of enamel and dentin are laid down followed by initial calcification?

A

-Apposition stage

43
Q

What stage do you have a series of reciprocal inductions occur between enamel organ and dental papilla outer cells?

A

-Apposition stage

44
Q

What is the first thing in the reciprocal induction order?

A

-IEE cells differentiate into Preameloblasts

45
Q

In the second step of reciprocal induction the preameloblasts induce what?

A

-Outer Dental papilla cells

46
Q

When the outer dental papilla cells are induced by preameloblasts what do they differentiate into?

A

-Preodontoblasts that continue to differentiate into odontoblasts

47
Q

When does the DEJ form?

A

-After disintegration of basement membrane

48
Q

When the odontoblasts retreat from the DEJ what do they leave behind?

A

-Odontoblastic processes within predentin

49
Q

What is the space containing the odontoblastic process called?

A

-Dentinal tubule

50
Q

What is formed by early secretory ameloblasts?

A

-Prismless enamel

51
Q

What are formed by Tomes processes of late secretory ameloblasts?

A

-Enamel prisms

52
Q

What does predentin induce?

A

-Differentiation of preameloblasts into ameloblasts

53
Q

How many stages are there in the ameloblast life cycle?

A

7

54
Q

What is the first stage of the ameloblast life cycle?

A

-Inner enamel epithelial cell

55
Q

In the life cycle of the ameloblast what comes after the IEE cell?

A

-Preameloblasts

56
Q

In the life cycle of the ameloblasts what comes after the preameloblasts?

A

-Initial secretory ameloblasts

57
Q

In the life cycle of the ameloblasts what comes after the initial secretory ameloblasts?

A

-Secretory ameloblasts

58
Q

In the life cycle of the ameloblasts what comes after the secretory ameloblasts?

A

-Smooth -ended maturation ameloblasts

59
Q

What do smooth ended maturation ameloblasts do?

A

-Removal of protein and water

60
Q

In the life cycle of the ameloblasts what comes after the smooth-ended maturation ameloblasts?

A

-Ruffled-ended maturation ameloblasts

61
Q

What does the ruffled-ended maturation ameloblasts do?

A

-Introduction of inorganic material

62
Q

In the life cycle of the ameloblasts what comes after the ruffled-ended maturation ameloblasts?

A

-Protective ameloblasts

63
Q

What is the protective ameloblast?

A

-Enamel cuticle

Oral Biology 2020 (21 decks)

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