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Oral Biology 2020 > Dentin Pulp Complex TEST #3 2/23/17 > Flashcards

Dentin Pulp Complex TEST #3 2/23/17 Flashcards

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1
Q

What is the main cellular component of the tooth?

A

-Pulp

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2
Q

What is the main mineralized structural component of the tooth?

A

-Dentin

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3
Q

What is the main mineralized protective component of the tooth?

A

-Enamel

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4
Q

What is the percentages of material in dentin?

A
  • 70% inorganic (hydroxyapatite)
  • 20% Organic
  • 10% Water
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5
Q

Are the dentin tubules fluid filled?

A

-Yes

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6
Q

What form does collagen have?

A

-Triple helix

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7
Q

Can fluoride, magnesium, and zinc be incorporated into the inorganic material of dentin?

A

-Yes

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8
Q

In Dentin, what are the shapes of the Hydroxyapatite crystals?

A

-Flattened into rectangular plates

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9
Q

T/F Bone is harder than dentin

A

False

-Dentin is slightly harder than bone

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10
Q

In the 20% of the organic material found in dentin what percentage of that is collagen?

A

-90%

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11
Q

In the 20% of the organic material found in dentin what percentage of that is non-collagenous proteins?

A

-10%

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12
Q

In the organic material in dentin what is the main type of collagen found?

A

-Type I

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13
Q

What are the three types of collagen found in the organic material of dentin?

A
  • Type I
  • Type III
  • Type V
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14
Q

What is the purpose of the fibrillar collagen scaffold?

A

-It is where HA crystals are laid down

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15
Q

Dentin Sialophosphoprotein (DSPP) are cleaved into what three dentin specific non-collagenous proteins of dentin?

A
  • DSP
  • DGP
  • DPP
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16
Q

What enzyme cleaves DSPP?

A

-BMP-1

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17
Q

What cleaved product of DSPP is a proteoglycan?

A

-DSP

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18
Q

What cleaved product of DSPP is a glycoprotein?

A

-DGP

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19
Q

What is the purpose of DGP?

A

-Helps in mineralization

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20
Q

What is the purpose of DSP?

A

-Prevent mineralization

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21
Q

What cleaved product of DSPP binds lots of Ca2+ to initiate HA formation?

A

-DPP

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22
Q

What cleaved product of DSPP is attached to collagen?

A

-DPP

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23
Q

What can defects in DSPP cause?

A

-Dentinogenesis imperfect Type II and III

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24
Q

What is type I dentinogenesis imperfecta caused by?

A

-Defect in Collagen I

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25
Q

What happens with the pulp chamber in type I dentinogenesis imperfecta?

A

-Fills with abnormal dentin

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26
Q

What is type II dentinogenesis imperfecta caused by?

A

-DSPP defect

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27
Q

What happens with the pulp chamber in type II dentinogenesis imperfecta?

A

-Fills with abnormal dentin

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28
Q

What type of pulp chamber do you see in type III dentinogenesis imperfecta?

A

-Enlarged pulp chambers

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29
Q

What type of dentinogenesis imperfecta results from Osseogenesis imperfecta?

A

-Type I

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30
Q

What are the results of type III dentinogenesis imperfecta?

A

-Hypo-mineralization

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31
Q

What causes type III dentinogenesis imperfecta?

A

-Failure of DSPP expression

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32
Q

What origin are dentin cells?

A

-Mesenchymal

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33
Q

T/F Odontoblasts continually secrete dentin throughout the course of their lives.

A

True

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34
Q

What does the dentin-pulp complex arise from?

A

-Dental papilla

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35
Q

When odontoblasts differentiate what zone to they fill?

A

-Acellular zone between the IEE and dental papilla

36
Q

T/F There is no vascular support for the developing Odontoblasts

A

False

-There is vascular support

37
Q

What is the interface between the enamel and dentin when they are in direct apposition?

A

-DEJ

38
Q

What type of edge does the DEJ have?

A

-Scallped

39
Q

What are two reasons the shape of the DEJ is critical?

A
  • Define the shape of the crown

- Keeps denting directly attached to enamel during loading (no shearing)

40
Q

How is the DEJ bound together?

A

-Merging of the Enamel HA and the dentin HA in ridges

41
Q

What is the DEJ most pronounced?

A

-Under the crown

42
Q

What is the first layer of dentin formed?

A

-Mantle Dentin

43
Q

What is the only part of dentin that is not tubular?

A

-Mantle Dentin

44
Q

What type of fibers are .1-.2 mm collagen III fibrils that are associated with fibronectin during dentin formation?

A

-Von Korff’s fibers

45
Q

Developing odontoblasts begin extending processes known as what?

A

-Tomes’ fibers

46
Q

Where do the tome’s fibers extend into?

A

-Developing matrix

47
Q

If the Mantle dentin penetrates the IEE what feature does that give?

A

-Enamel spindles

48
Q

What is the future odontoblast process?

A

-Tome’s fibers

49
Q

What does dentin start as when it is deposited?

A

-Non-mineralized organic matrix known as predentin

50
Q

Where does mineralization start for dentin?

A

-within the Odontoblasts secreted matrix vesicles

51
Q

What are the two types of dentin mineralization?

A
  • Globular

- Linear

52
Q

What happens to secreted matrix vesicles from dentin?

A

-They rupture and release mineralized matrix crystals

53
Q

What type of proteins regulate subsequent dentin formation that results in tubular primary dentin?

A

-Non-collagenous matrix proteins

54
Q

After the DEJ formation what type of dentin begins to form?

A

-Circumpulpal

55
Q

What initiates odontoblastic differentiation in the root?

A

-Hertwig’s root sheath (HERS)

56
Q

What do HERS eventually break into?

A

-Cell rests of Malaxxez

57
Q

What is the first dentin formed during development that comprises the mantle dentin and the initial deposition of circumpulpal dentin?

A

-Primary Dentin

58
Q

What type of dentin is tubular dentin that is laid down subsequent to root formation?

A

-Seondary dentin

59
Q

How long is secondary dentin produced?

A

-Throughout life

60
Q

What section of dentin tubules have a sigmoidal curve?

A

-Coronal dentin

61
Q

What section of dentin tubules have a much straighter tube?

A

-Root dentin

62
Q

Does primary or secondary dentin have a sigmoidal curve?

A

-Primary

63
Q

When is tertiary dentin produced?

A

-In response to insult

64
Q

What is the purpose of tertiary (pathological) dentin?

A
  • Seal off dentinal tubules
  • Form bridges between dentin and restoration
  • Response to trauma
65
Q

If the trauma does not damage odontoblasts what classification of tertiary dentin forms?

A

-Reactionary

66
Q

If the trauma damages damages odontoblasts what classification of tertiary dentin forms?

A

-Reparative

67
Q

What does the damage of odontoblasts do?

A

-Recruitment and differentiation of mesenchymal cells forming new odontoblasts

68
Q

What are the 3 main structures found in dentin?

A
  • Dentin tubules
  • Peritubular dentin
  • Intertubular dentin
69
Q

T/F Tertiary dentin more resembles bone than dentin

A

True

70
Q

Where is the density of the dentin tubules higher at DEJ or near the Pulp?

A

-near the Pulp

71
Q

What are the dentin tubules surrounded by?

A

-Highly calcified peritubular dentin

72
Q

T/F Secondary branches can form from the dentinal tubules

A

True

73
Q

What is the response of the ondontoblasts when caries are traveling down the tubules?

A

-Tertiary dentin is formed

74
Q

When you seal off the dentin tubule with tertiary dentin and trap the air inside the tubule what is that known as?

A

-Dead tracts

75
Q

What is the collective term for tubules that have become occluded?

A

-Sclerotic dentin

76
Q

What does sclerotic dentin look like in a ground section?

A
  • Glassy

- Translucent

77
Q

T/F As you get older you have less porous dentin

A

True

78
Q

What are areas of hypomineralized dentin known as?

A

-Interglobular dentin

79
Q

What is formed when fusion of mineral containing vesicles fail?

A

-Interglobular dentin

80
Q

What can interglobular dentin be associated with?

A
  • Vitamin D deficiency

- Fluoride exposure during initial dentin formation

81
Q

Where is interglobular dentin more commonly found?

A

-Near mantle dentin

82
Q

Dentin matrix is deposited continually at how much per day?

A

-4 microns

83
Q

Every 5 days there is a layer of dentin deposited that has a noticeably different orientation of collagen fibers forming lines known as what?

A

-lines of von Ebner (Seen at 20 micron intervals)

84
Q

What are enhanced lines that indicate disruption of tooth formation?

A

-Contour lines of Owen

85
Q

Where do you find the Granular layer of Tomes?

A

-Root Dentin (more granular toward the apical end of tooth)

Oral Biology 2020 (21 decks)

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