Final Chapter 4 Review Flashcards
What makes up the urinary system? 1. 2. 3. 4.
- 2 kidneys
- 2 ureters
- urinary bladder
- urethra
What transports urine from the kidneys to the bladder?
Ureters
What hormones are excreted by the urinary system?
- Erythropoietin
2. Renin
What does erythropoietin do?
Increases red blood cell production
What does the hormone renin do?
Causes increase in blood pressure
Is the kidney peritoneal or retroperitoneal?
Retroperitoneal
What is the concave medial border of the kidney called?
Hilum
What are the 7 functions of the urinary system?
- Filters blood to remove waste
- Storage/expulsion of urine
- Regulates blood volume/pressure
- Regulates blood ionic composition
- Secretes enzymes and hormones
- Regulates pH
- Glucogenesis
Put the kidney tissue layers in order from superficial to deep.
Paranephric fat, Renal fascia, Perinephric fat, Fibrous capsule
Which kidney tissue layer is made up of dense irregular connective
tissue that is directly adhered to kidney; maintains kidney’s shape, protects from trauma and prevents infection?
Fibrous Capsule
What kidney tissue layer is made up of adipose tissue that varies in
thickness; surrounds kidney and offers
protection?
Perinephric Fat
What kind of kidney tissue is made up of dense irregular connective tissue
that anchors the kidney?
Renal Fascia
What kind of kidney tissue is made up of adipose tissue that lies between renal fascia and peritoneum?
Paranephric Fat
How many lobes does a kidney have?
8-15
What is the outter layer inside the kidney?
Renal Cortex
What is the inner layer inside the kidney?
Renal Medulla
What does each renal papilla empty into?
Minor Calyx
What do the minor calyces merge to form?
Major Calyx
How many major calyx per kidney?
2-3
Major calyces merge to form what?
Renal Pelvis
What function does the renal pelvis have?
Collects and transports urine to the ureters.
What does the kidney do?
Filters the blood and helps
regulate blood volume via removal
and reabsorption of water and ions
What supplies the kidneys with blood?
Renal Arteries
How much of the cardiac output does the kidneys receive?
25%
What is the blood flow of the kidneys?
Renal Artery > Segmental Artery > Interlobar Artery > Arcuate Artery > Interlobular Artery > Afferent Arterioles > Gomerular Capillaries > Efferent Arterioles > Peritubular Capillaries > Interlobular Veins > Arcuate Veins > Interlobar Veins > Segmental Veins > Renal Vein
What innervates the kidney?
Renal Plexus
What is the functional unit of the kidneys?
Nephrons
What are individual nephrons connected to in the kidneys?
Collecting Duct
What do the collecting ducts empty into?
Minor Calyx
What are the 2 regions of the nephron?
- Renal Corpuscle
2. Renal Tubule
What makes up the renal corpuscle in the nephron?
1.
2.
- Glomerulus
2. Glomerular Capsule
What makes up the renal tubule in the nephron?
1.
2.
3.
- Proximal Convoluted Tubule
- Loop of Henle
- Distal Convoluted Tubule
What are the two types of nephrons?
- Cortical Nephron
2. Juxtamedullary Nephron
Which type of nephron is the most common?
Cortical Nephrons?
Where does the cortical nephron receive blood from?
Peritubular Capillaries
Where do juxtamedullary nephrons receive blood from?
Vasa Recta
Which type of nephron is responsible for making very dilute or very concentrated urine?
Juxtamedullary Nephrons
Where are nephrons located in the kidney?
Renal Cortex
Which type of nephron’s loop of henle extends beyond the renal cortex into the renal medulla?
Juxtamedullary Nephron
What 3 processes are involved in urine formation?
- Glomerular Filtration
- Tubular Reabsorption
- Tubular Secretion
What is Glomerular Filtration?
Substance movement from glomerulus to bowman’s space.
What is tubular reabsorption?
Substance movement from tubular fluid back to blood.
What is tubular secretion?
Substance movement from blood to tubular fluid.
What two parts compose the renal corpuscle?
- Glomerulus
2. Gomerular Capsule
What is the glomerulus?
Group of capillaries
What 3 layers make up the glomerular capsule?
- Visceral Layer
- Parietal Layer
- Bowman’s Space
What makes up the visceral layer of the glomerulus capsule?
Podocytes
What makes up the parietal layer of the glomerulus capsule?
Simple Squamous Epithelium
What does bowman’s capsule do?
As blood filters, water and filtered substances go into this space.
Thin, porous, and negatively charged
structure formed by glomerulus and
visceral layer of glomerular capsule
Filtration Membrane
What 3 layers of Filtration Membrane must substances pass through to become part of filtrate?
- Endothelium of glomerulus
- Basement membrane of glomerulus
- Visceral layer of glomerular capsule
What kind of endothelium makes up the endothelium layer in the filtration membrane?
Fennestrated endothelium
What happens after the glomerular filtrate is in Bowman’s Capsule?
It flows into the renal tubules
What are the 3 parts of the renal tubule?
- Proximal Convoluted Tubule
- Loop of Henle
- Distal Convoluted Tubule
What do Collecting Tubules collect filtrate from?
Distal Convoluted Tubule
What is the last structure that can modify filtrate?
The collecting duct
Where is water and Na+ reabsorbed in the presence of ADH and aldosterone?
The collecting duct
What is path of glomerular filtrate?
Bowman’s Capsule > Proximal Convoluted Tubule > Loop of Henle > Distal Convoluted Tubule > Collecting Duct > Renal Papilla > Minor Calyx > Major Calyx > Renal Pelvis > Ureter > Urinary Bladder > Urethra
What dictates the amount of filtrate per minute in the kidneys?
Filtration Pressure
What controls filtration pressure?
Glomerular Blood Pressure and Blood Flow
Higher pressure =
More filtrate formed
What is average Glomerular Filtration Rate?
125 ml/minute or 150 - 180 L/day
How much filtrate is reabsorbed?
99%
What percent of filtrate is released via urine?
1%
Insufficient time for reabsorption, urine output rises leading to dehydration and electrolyte depletion.
Increased GFR
Sluggish flow through the nephron too much wastes reabsorbed (toxicity).
Decreased GFR
What makes up the Juxtaglomerular Apparatus?
1.
2.
3.
- Granular Cells
- Macular Densa
- Extraglomerular Mesangial Cells
What are Granular Cells?
Modified smooth muscle of afferent arterioles.
What is macular densa?
Modified epithelial cells in DCT that monitor ions.
What are extraglomerular mesangial cells?
Located between the granular cells and arterioles; contract and phagocytize filtered particles.
When is renin secreted?
when blood pressure or GFF
is reduced = aldosterone
What are the 3 layers of the ureter superficial to deep?
- Adventitia
- Muscularis
- Mucosa
What is adventitia of the bladder?
areolar connective tissue
What is the muscularis of the ureter?
Two smooth muscle layers
What is the mucosa of the ureter?
Transitional Epithelium
What are constriction points in the ureter?
Common places for kidney stones to get stuck.
What are three constriction points?
- Junction of renal pelvis and ureter
- Pelvic inlet
- Entrance to bladder
What is the bladder?
Muscular sac that holds urine until
micturition.
Where is the female bladder?
Anteroinferior to uterus and anterior
to vagina.
Where is the male bladder?
Anterior to rectum and superior to
prostate gland.
Where do the ureters enter the bladder?
Ureteric orifices
What drains the bladder?
The Urethra
Imaginary lines connecting the ureteric
orifices to the urethra forms the…..?
Trigone
What 4 tunics compose the bladder wall deep to superficial?
- Mucosa
- Submucosa
- Muscularis
- Adventitia
What does the mucosa tunic line?
The lumen
What makes up the mucosa that lines the lumen?
Transitional epithelium
What makes up the submucosa tunic?
Irregular Connective Tissue
What makes up the muscularis tunic?
3 smooth muscle layers called the detrusor muscle.
What is the Adventitia tunic?
Outer layer of connective
tissue of urinary bladder.
What is the fibromuscular tube that conducts urine from bladder to outside?
Urethra
What two sphincters control the urethra?
- Internal Urethral Sphincter
2. External Urethral Sphincter
Which urethral sphincter is voluntary skeletal muscle controlled by somatic nervous system?
External Urethral Sphincter
Which urethral sphincter is involuntary smooth muscle found surrounding neck of bladder?
Internal Urethral Sphincter
How is the male and female urethra different?
1.
2.
- Female urethra shorter, no reproductive function.
2. Male urethra longer, urinary and reproductive function.
What 3 part make up the male urethra?
- Prostatic urethra
- Membranous urethra
- Spongy urethra
What are the steps of micturition?
- When bladder fills with 200-300mls of urine, stretch activates baroreceptors that signal micturition center in pons.
- Pelvic splanchnic nerves stimulate detrusor muscle to contract and internal urethral sphincter to relax.
- Relax external urethral sphincter when ready to void urine (voluntary).
- Sympathetic nervous system inhibits
detrusor muscle and contracts internal
urethral sphincter.
What is a UTI?
Occurs when bacteria enter the urinary
tract.
Why are women more susceptible to UTI’s?
Shorter urethra and proximity to anus
What increases the risk of UTI in both sexes?
1.
2.
- Intercourse
2. Urinary catheter
What are symptoms of UTI?
Dysuria, frequent urination, pressure in pubic region; if spread to kidneys can cause nausea, back pain, and occasionally nausea and vomiting.
What are renal calculi?
Kidney Stones
What are three risk factors of kidney stones?
- Inadequate Hydration
- Frequent UTI’s
- Reduced Urinary Flow and Volume
Are kidney stones more common in males or females?
Males
What is used to break up kidney stones?
Lithotripsy-ultrasound