F3: Fecalysis (Part 3: Osmotic Gap-Secretory vs. Osmotic) Flashcards
OSMOTIC GAP
Formula for computing osmotic gap?
290 - {2 (fecal Na + fecal K)}
OSMOTIC GAP
Osmotic or Secretory Diarrhea?
Greater than 50 mOsm/kg
Osmotic diarrhea
OSMOTIC GAP
Osmotic or Secretory Diarrhea?
Less than 50mOsm/kg
Secretory Diarrhea
OSMOTIC GAP
In secretory diarrhea, osmotic is lower due to?
Increase in electrolyte (NA, CL)
TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA
Identify reference value according to test:
Total fecal osmolarity
290 mOsm/kg
TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA
Identify reference value according to test:
Normal fecal sodium
30 mmol/L
TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA
Identify reference value according to test:
Normal fecal potassium
75 mmol/L
TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA
Identify reference value according to test:
pH
7-9
TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA
< 5.6 (malabsorption of sugars)
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic
MECHANISM: Increased secretion of water and electrolytes
Secretory
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic:
Increased quantities of osmotically active solutes (undigested food in the lumen)
Osmotic
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic:
COMMON CAUSES: Enterotoxin-producing organisms, V. cholera, Salmonella, Shigella, E. coli, Clostridium, Staphylococcus Protozoa, Virus
Secretory
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic:
COMMON CAUSES: Maldigestion (pancreatic insufficiency) Lactose intolerance, Malabsorption, Celiac disease, Tropical sprue
Identify if Secretory or Osmotic:
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic:
LABORATORY TEST: S
Secretory
DIFFERENTIAL FEATURES FOR DIARRHEA
Identify if Secretory or Osmotic:
LABORATORY TEST: O
Osmotic