F3: Fecalysis (Part 3: Osmotic Gap-Secretory vs. Osmotic) Flashcards

1
Q

OSMOTIC GAP

Formula for computing osmotic gap?

A

290 - {2 (fecal Na + fecal K)}

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2
Q

OSMOTIC GAP

Osmotic or Secretory Diarrhea?

Greater than 50 mOsm/kg

A

Osmotic diarrhea

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3
Q

OSMOTIC GAP

Osmotic or Secretory Diarrhea?

Less than 50mOsm/kg

A

Secretory Diarrhea

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4
Q

OSMOTIC GAP

In secretory diarrhea, osmotic is lower due to?

A

Increase in electrolyte (NA, CL)

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5
Q

TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA

Identify reference value according to test:

Total fecal osmolarity

A

290 mOsm/kg

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6
Q

TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA

Identify reference value according to test:

Normal fecal sodium

A

30 mmol/L

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7
Q

TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA

Identify reference value according to test:

Normal fecal potassium

A

75 mmol/L

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8
Q

TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA

Identify reference value according to test:

pH

A

7-9

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9
Q

TESTS TO DIFFERENTIATE THE MECHANISMS OF DIARRHEA

A

< 5.6 (malabsorption of sugars)

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10
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic

MECHANISM: Increased secretion of water and electrolytes

A

Secretory

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11
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:

Increased quantities of osmotically active solutes (undigested food in the lumen)

A

Osmotic

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12
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:

COMMON CAUSES: Enterotoxin-producing organisms, V. cholera, Salmonella, Shigella, E. coli, Clostridium, Staphylococcus Protozoa, Virus

A

Secretory

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13
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:

COMMON CAUSES: Maldigestion (pancreatic insufficiency) Lactose intolerance, Malabsorption, Celiac disease, Tropical sprue

A

Identify if Secretory or Osmotic:

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14
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
LABORATORY TEST: S

A

Secretory

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15
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
LABORATORY TEST: O

A

Osmotic

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16
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
OSMOTIC GAP: Less than 50 mOsm/kg

A

Secretory

17
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
OSMOTIC GAP: Greater than 50 mOsm/kg

>75 Osm/kg for strasinger

A

Osmotic

18
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
PH: > 5.6

A

Secretory

19
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
PH: < 5.3

A

Osmotic

20
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
REDUCING SUBSTANCES: Negative

A

Secretory

21
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
REDUCING SUBSTANCES: Positive

A

Osmotic

there are sugars present in the stool

22
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
FECALYSIS FINDINGS: RBC, WBC, mucus

A

Secretory

23
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
FECALYSIS FINDINGS: Meat fiber, fats, lactose watery and Gaseous (Partially/undigested food, gas)

A

Osmotic

24
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
STOOL NA (SODIUM): > 90 mmol/L

A

Secretory

25
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:

STOOL NA (SODIUM): < 60 mmol/L

A

Osmotic

26
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:

STOOL OUTPUT IN 24 HOURS: > more than 200 g

A

Secretory

27
Q

DIFFERENTIAL FEATURES FOR DIARRHEA

Identify if Secretory or Osmotic:
STOOL OUTPUT IN 24 HOURS: less than 200 g

A

Osmotic

28
Q

COMMON FECAL TESTS FOR DIARRHEA

Identify if Secretory or Osmotic:

  • Stool culture
  • Parasite examination
  • Rotavirus immunoassay
  • Fecal leukocytes
A

Secretory

29
Q

COMMON FECAL TESTS FOR DIARRHEA

Identify if Secretory or Osmotic:
* Fecal fats
* Muscle fiber
* Trypsin
* Clinitest
* D xylose tolerance Lactose tolerance Fecal electrolytes, pH, osmolality

A

Osmotic

30
Q

COMMON FECAL TESTS FOR DIARRHEA

Identify if Secretory or Osmotic:

Fecal tests are more on identifying different toxin producing microorganisms

A

Secretory

again, these are causes of secretory diarrhea

31
Q

COMMON FECAL TESTS FOR DIARRHEA

Identify if Secretory or Osmotic:

More on identifying reducing substances,
electrolytes, osmolality, etc.

A

Osmotic