Exam1Lec6Cartilage Flashcards
What are the three types of cartilage?
Hyaline
Elastic
Fibrocartilage
Which cartilage is most abundant?
Hyaline
a type of specialized connective tissue
Where is hyaline found?
found in the embryo as early skeleton, articular surfaces, joints, epiphyseal plates and the respiratory system.
epiphyseal plate is the cartilagenous plate between diaohyses and epiphyses
Where is elastic cartilage is found?
auricle, epiglottis, auditory tubes
Where is fibrocartilage found?
Intervetebral discs and symphysis pubis, menisci, joints
What is hyaline cartilage composed of?
Lacunae which is a space that houses chondrocytes, and surrounded by a glassy appearing EC matrix
fxn is provided by EC matric
cellulary composition=chondrocytes which are housed in lacunae & surrounded by ECM
What is the primary fiber type in the EC matrix?
Collagen type 2
this is made and maintaned by chondrocytes.
chondrocytes produce type 1 collagen
ECM also contains collagen IX, X, and XI
What is collagen 1?
collagen we see in bone (all of the ec matrix is replaced by bone matrix)
What forms proteoglycan matrixes in the ground susbtance?
EC matrix contains glycosaminoglycans, hyaluronic acid, chondroitin sulfate and keratin sulfate
The matrix hold the hydration high for the cartilage. Why is this impt?
Diffusion of nutrients since cartilage is an avascular and for cushioning bc water does not compress
cartilage has no vascular supply, and water makes it easier for diffusion
What type of tissue is perichondrium? What does it contain?
Dense irregular connective tissue that contains chondroBLASTS whic hare the precursor for chondrocytes.
What is appositional growth?
Where chondroblasts differentiate to chondrocytes to add new cells to the outside of the cartilage
seen both in bone and cartilage
growth is to the surface of the cartilage
What is interstitial growth?
Growth through the division of chondrocytes within the lacunae which lay down new matrix and form new lacunae
you see isogenous groups where cells inside matrix divides and grows apart. This is not seen in bone.
growth is from the inside of cartilage
How can perichondrium be found?
It usually surrounds the hyaline cartilage in some areas like the trachea. In other areas it may cover some of the surfaces. It is absent at articular surfaces of joints
surrounds hyaline + elastic cafrtilage
Chondrocytes are sometimes found in clusters termed
isogenous groups
cluster of chondrocytes