Exam 3 Class Review Questions

Question 1

Pernicious anemia is caused by deficiency of what?

Answer 1

B12

Question 2

Name the 3 pathways for T cell tolerance.

Answer 2

1: Clonal abortion
2: Functional deletion
3: T cell suppression

Question 3

Is Lupus more frequent in men or women?

Answer 3

Women

Question 4

Type 2 diabetes and latent adult diabetes are the same. True or false?

Answer 4

False

Question 5

Low TSH, elevated Free T4 is associated with what disease?

Answer 5

Graves disease

Question 6

BJ proteins are soluble and insoluble at what temperatures?

Answer 6

Precipitate at 60 and Dissolve at 100

Question 7

Tolerance is a lack of response to what?

Answer 7

Self antigens

Question 8

AIH (Autoimmune hepatitis) is more common in males or females?

Answer 8

Females

Question 9

Discoid lupus is always limited to what?

Answer 9

Skin

Question 10

What is most common form of MS?

Answer 10

Progressive Relapsing

Question 11

What are the 2 types of syndromes you see bence jones proteins in?

Answer 11

Typical Monoclonal Gammopathy
Free light chain disease

Question 12

Which autoimmune disorder is produced by T cells/Antibodies against antigens isolated to a single organ?

Answer 12

Organ specific disorders

Question 13

In MM, what percent of patients have broadly disseminated destruction of the skeleton?

Answer 13

90%

Question 14

What are the two most frequent causes of death in SLE?

Answer 14

Renal Failure and Chronic Infectious disease

Question 15

What is the most frequent cause of death for those w/RA?

Answer 15

Cardiovascular disease

Question 16

Which is not 1 of the 4 pathways of B cell tolerance?

Clonal exhaustion
Functional deletion
Clonal deletion
Clonal abortion

Answer 16

Clonal Deletion

Question 17

What IG classes are associated with Rheumatoid Factor?

Answer 17

IgA, IgG, and IgM

Question 18

% of patients who take hydra…………..

Answer 18

4%

Question 19

Citrullination is the process of proteins being altered during inflammation. T or F?

Answer 19

True

Question 20

T/F: RF testing is more sensitive than cyclic citrullinated peptide (CCP)

Answer 20

False

Question 21

What is the most common heavy chain disease?

Answer 21

Alpha Heavy Chain

Question 22

List 3 factors that influence the development of autoimmune disorders

Answer 22

Genetic predisposition
Environmental
Patient Age

Question 23

What are 4 pathways of B cell tolerance?

Answer 23

Clonal abortion
Functional deletion
clonal exhaustion
Antibody forming cell blockade

Question 24

What stage of autoimmune disease is associated w/active disease state?

Answer 24

Propagation

Question 25

As a B cell matures, it becomes more susceptible to tolerization. True or false?

Answer 25

False, becomes less susceptible

Question 26

RA is a multisystem autoimmune disorder. True or false?

Answer 26

True

Question 27

Which cytokine is essential for survival and growth of myeloma cells?

Answer 27

IL-6

Question 28

In SLE, what renal disease progression is unpredictable?

Answer 28

glomerulonephritis

Question 29

Lupus is 5-10 times more frequent in women than men. True or false?

Answer 29

False, 10-15 times

Question 30

Immunoelectrophoresis determines blood levels of what Igs?

Answer 30

IgGAM

Question 31

What is the first Ig tested to identify celiac?

Answer 31

IgA

Question 32

FISH testing stands for?

Answer 32

Fluorescent in situ hybridization

Question 33

Postmenopausal women that begin estrogen therapy are more likely to develop lupus. True or False?

Answer 33

True

Question 34

RF is associated with what 3 Igs?

Answer 34

IgM, IgA, IgG

Question 35

4 different forms of lupus...?

Answer 35

SLE Discoid Drug induced Neonatal

Question 36

Which cell types are involved in pathogenesis of SLE?

Answer 36

T cells, B cells, Dendritic cells

Question 37

What is the most common Antibody in MM?

Answer 37

IgG

Question 38

Which type of antibodies are the only autoantibodies that may be used to monitor SLE?

Answer 38

Anti-dsDNA

Question 39

What causes renal issues in SLE?

Answer 39

Buildup of immune complexes in the glomerulus

Question 40

What is the unique characteristic of BJ proteins in regard to heating?

Answer 40

Soluble at room temp, precipitates 60-70 degrees and dissolves at 100 degrees

Question 41

What % of patients are diagnosed w/ MM without symptoms?

Answer 41

20%

Question 42

Non-classified group of autoimmune hemolytic anemia?

Answer 42

paroxysomal cold hemoglobinuria and atypical AIHA

Question 43

MM has an increase in CD4 cells and decrease in CD8 cells. True or false?

Answer 43

False

Question 44

Which is an important biological marker for MM? ESR CRP Carcinoembryonic antigen BJ proteins

Answer 44

BJ proteins

Question 45

Bone pain is a common symptom of Waldenstrom Macroglobulinemia. True or false?

Answer 45

False

Question 46

MM requires _________ bone marrow plasma cells for diagnostic criteria.

Answer 46

Greater than 10%

Question 47

What exogenous factors may influence development of autoimmunity?

Answer 47

UV, drugs, infectious diseases, chronic infections, viral infections

Question 48

SLE affects the joints, connective tissues, and what other system?

Answer 48

Collagen system

Question 49

MM is the most common form of dysproteinemia. True or false?

Answer 49

True

Question 50

Which of the following are factors associated with RA: Genetic Hormonal Environmental

Answer 50

Genetic and hormonal

Question 51

What are the sequential stages of autoimmune disease?

Answer 51

1. Initiation 2. Propagation 3. Resolution