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Immuno > CH 2 - Soluble Mediators > Flashcards

CH 2 - Soluble Mediators Flashcards

1
Q

The complement system is:

A
  • A heat-labile series of plasma proteins
  • Composed of many proteinases
  • Composed of three interrelated pathways
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2
Q

All of the following are complement-controlling proteins except:

  • C1 (INH)
  • Factor I
  • Factor H
  • C3
A

C3

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3
Q

The three complement activation pathways converge at the
point of cleavage of complement component _____.

A

C3

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4
Q

All of the following result from complement activation except:

  • Decreased cell susceptibility to phagocytosis
  • Blood vessel dilation and increased vascular permeability
  • Production of inflammatory mediators
  • Cytolysis or hemolysis
A

Decreased cell susceptibility to phagocytosis

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5
Q

Activation sequence of the classic
complement pathway:

A

C1, 4, 2, 3, 5, 6, 7, 8, 9

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6
Q

Which complement component is present in the greatest
quantity in plasma?

A

C3

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7
Q

Arrange the three stages of the classic complement pathway
in their correct sequence:

  • Enzymatic activation
  • Membrane attack
  • Recognition
A

1) Recognition

2) Enzymatic activation

3) Membrane attack

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8
Q

Fixation of the C1 complement component is related to each of the following factors except:

  • Molecular weight of the antibody
  • The presence of IgM antibody
  • The presence of most IgG subclasses
  • Spatial constraints
A

Molecular weight of the antibody

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9
Q

At which stage does the complement system reach its full
amplitude?

A

C3

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10
Q

Which of the following is a component of the membrane a

A

C2

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11
Q

The final steps (C8 and C9) in complement activation lead to:

A

Cell lysis

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12
Q

Activation by antigen–antibody complexes represents:

A

Classic pathway

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13
Q

Generation of an active (C3b, Bb) C3 convertase is seen in:

A

Alternative pathway

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14
Q

Activation by microbial and mammalian cell surfaces occurs in:

A

Alternative pathway

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15
Q

The ____________ terminates in a membrane attack complex

A
  • Classic pathway
  • Alternative pathway
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16
Q

The alternative complement pathway is (can be):

A
  • Considered to be a predominantly, non–antibody-initiated
    pathway
  • Activated by factors such as endotoxins
17
Q

Which of the following conditions can be associated with
hypercomplementemia?

  • Myocardial infarction
  • Systemic lupus erythematosus
  • Glomerulonephritis
  • Subacute bacterial endocarditis
A

Myocardial infarction

18
Q

A complement deficiency state associated with a deficiency of
C2 is:

A

Recurrent pyogenic infections

19
Q

A complement deficiency state associated with C5 dysfunction
is:

A

Leiner disease

20
Q

A complement deficiency state associated with a deficiency of
C6 and C7 is:

A

Raynaud phenomenon

21
Q

A complement deficiency state associated with a deficiency of
C8 is:

A

Xeroderma pigmentosa

22
Q

A (the) nonspecific component(s) of the immune system is
(are):

A
  • Complement
  • T cells
23
Q

Transforming growth factors:

A
  • Are products of virally transformed cells
  • Can be a potent inhibitor of IL-1–induced T cell proliferation in their beta form
  • Are important in inflammation, tumor defense, and cell growth
24
Q

Which activity is associated with interferon?

  • Enhances phagocytosis
  • Retards expression of specific genes
  • Promotes complement-mediated cytolysis
  • Interferes with viral replication
A

Interferes with viral replication

25
Q

Tumor necrosis factor (TNF) differs from IL-1 in that TNF is
not able to:

A

Stimulate T cell proliferation

26
Q

The characteristic associated with tumor necrosis factor is:

A

Encoding gene located in the HLA region between the HLADR and HLA-B loci

27
Q

The characteristic associated with colony-stimulating factor is:

A

Stimulates hematopoietic growth factor

28
Q

The characteristic associated with growth factors is:

A

Induces phenotype transformation in nonneoplastic cells

Immuno (23 decks)

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