CH 2 - Soluble Mediators Flashcards
The complement system is:
- A heat-labile series of plasma proteins
- Composed of many proteinases
- Composed of three interrelated pathways
All of the following are complement-controlling proteins except:
- C1 (INH)
- Factor I
- Factor H
- C3
C3
The three complement activation pathways converge at the
point of cleavage of complement component _____.
C3
All of the following result from complement activation except:
- Decreased cell susceptibility to phagocytosis
- Blood vessel dilation and increased vascular permeability
- Production of inflammatory mediators
- Cytolysis or hemolysis
Decreased cell susceptibility to phagocytosis
Activation sequence of the classic
complement pathway:
C1, 4, 2, 3, 5, 6, 7, 8, 9
Which complement component is present in the greatest
quantity in plasma?
C3
Arrange the three stages of the classic complement pathway
in their correct sequence:
- Enzymatic activation
- Membrane attack
- Recognition
1) Recognition
2) Enzymatic activation
3) Membrane attack
Fixation of the C1 complement component is related to each of the following factors except:
- Molecular weight of the antibody
- The presence of IgM antibody
- The presence of most IgG subclasses
- Spatial constraints
Molecular weight of the antibody
At which stage does the complement system reach its full
amplitude?
C3
Which of the following is a component of the membrane a
C2
The final steps (C8 and C9) in complement activation lead to:
Cell lysis
Activation by antigen–antibody complexes represents:
Classic pathway
Generation of an active (C3b, Bb) C3 convertase is seen in:
Alternative pathway
Activation by microbial and mammalian cell surfaces occurs in:
Alternative pathway
The ____________ terminates in a membrane attack complex
- Classic pathway
- Alternative pathway
The alternative complement pathway is (can be):
- Considered to be a predominantly, non–antibody-initiated
pathway - Activated by factors such as endotoxins
Which of the following conditions can be associated with
hypercomplementemia?
- Myocardial infarction
- Systemic lupus erythematosus
- Glomerulonephritis
- Subacute bacterial endocarditis
Myocardial infarction
A complement deficiency state associated with a deficiency of
C2 is:
Recurrent pyogenic infections
A complement deficiency state associated with C5 dysfunction
is:
Leiner disease
A complement deficiency state associated with a deficiency of
C6 and C7 is:
Raynaud phenomenon
A complement deficiency state associated with a deficiency of
C8 is:
Xeroderma pigmentosa
A (the) nonspecific component(s) of the immune system is
(are):
- Complement
- T cells
Transforming growth factors:
- Are products of virally transformed cells
- Can be a potent inhibitor of IL-1–induced T cell proliferation in their beta form
- Are important in inflammation, tumor defense, and cell growth
Which activity is associated with interferon?
- Enhances phagocytosis
- Retards expression of specific genes
- Promotes complement-mediated cytolysis
- Interferes with viral replication
Interferes with viral replication
Tumor necrosis factor (TNF) differs from IL-1 in that TNF is
not able to:
Stimulate T cell proliferation
The characteristic associated with tumor necrosis factor is:
Encoding gene located in the HLA region between the HLADR and HLA-B loci
The characteristic associated with colony-stimulating factor is:
Stimulates hematopoietic growth factor
The characteristic associated with growth factors is:
Induces phenotype transformation in nonneoplastic cells
