CH 21 - Immunoproliferative Disorders

Question 1

Polyclonal gammopathies can be exhibited as a secondary
manifestation of all the following except:

a. Chronic infection
b. Chronic liver disease
c. Multiple myeloma
d. Rheumatoid connective disease

Answer 1

c. Multiple myeloma

Question 2

What is the most frequent cause of death in a patient with multiple myeloma?

Answer 2

Infectious disease

Question 3

Patients with multiple myeloma have defects in:

Answer 3

Humoral immunity

AND

Synthesis of normal immunoglobulins

Question 4

What is the most consistent immunologic feature of multiple myeloma?

Answer 4

Synthesis of dysfunctional single monoclonal
proteins

AND

Synthesis of Ig chains or fragments

AND

Presence of M protein in serum and/or urine

Question 5

Bence-Jones proteins are soluble at room temperature, form a
precipitate near ___1____, and then dissolve (resolubilize)
at ___2_____.

Answer 5

1) 60° C

2) 100° C

Question 6

M proteins are associated with all the following malignant
conditions except:

a. Multiple myeloma
b. Plasmacytoma
c. Malignant lymphoproliferative diseases
d. Lymphoma

Answer 6

Lymphoma

Question 7

Cryoglobulins are proteins that precipitate or gel at:

Answer 7

0° C

Question 8

Monoclonal gammopathy involves elevated levels of a single class and type of immunoglobulin referred to as:

Answer 8

Monoclonal Protein

AND

M Protein

AND

Paraprotein

Question 9

In light-chain disease, only ___1_____ or
____2____ monoclonal light chains are synthesized by a
one-cell clone.

Answer 9

1) Kappa

2) Lambda

Question 10

Multiple myeloma is also referred to as:

Answer 10

Plasma cell myeloma

AND

Kahler disease

AND

Myelomatosis

Question 11

Most patients with multiple myeloma manifest :

Answer 11

Bone Pain

Question 12

The figure above represents the serum electrophoresis of a patient with:

Answer 12

Multiple myeloma

Question 13

Patients with Waldenström’s macroglobulinemia exhibit
abnormally large amounts of:

Answer 13

IgM

Question 14

Monoclonal gammopathy of undetermined significance
(MGUS) represents a:

Answer 14

Monoclonal protein in patients with no features of
multiple myeloma or related malignant disorders

AND

Disorder that can evolve into a malignant monoclonal
gammopathy

AND

Serum monoclonal protein concentration less than
3 g/dL

Question 15

MGUS is characterized by all the following except:

a. Fewer than 10% plasma cells in the bone marrow
b. Presence of lytic bone lesions
c. Anemia
d. Hypercalcemia

Answer 15

Presence of lytic bone lesions

Question 16

Light-chain disease represents about ________ of
monoclonal gammopathies.

Answer 16

10% to 15%