CH 24 - Rheumatoid Arthritis

Question 1

Rheumatoid arthritis most frequently develops in:

Answer 1

Middle-aged women

Question 2

Worldwide the incidence of rheumatoid arthritis is:

Answer 2

1% to 2%

Question 3

Women are _______ likely than men to develop rheumatoid arthritis

Answer 3

Two to three times more

Question 4

Rheumatoid factor is defined as:

Answer 4

Antibodies with specificity for antigen determinants on the Fc fragment of human or certain animal IgG

Question 5

The principle of the rapid agglutination test is based on the reaction of patient ___1____ and ___2____ derived from gamma globulin.

Answer 5

1) Antibody

2) Antigen

Question 6

Arrange the steps in the pathogenesis of rheumatoid arthritis in the proper order:

a. Immunologic events perpetuate the initial inflammatory reaction
b. The primary etiologic factor initiates synovitis.
c. An inflammatory reaction in the synovium develops into a proliferative destructive process of tissue.

Answer 6

1) The primary etiologic factor initiates synovitis.

2) Immunologic events perpetuate the initial inflammatory reaction

3) An inflammatory reaction in the synovium develops into a proliferative destructive process of tissue.

Question 7

All the following are criteria for rheumatoid arthritis except:

a. Morning stiffness
b. Evening stiffness
c. Rheumatoid nodules
d. Radiographic changes

Answer 7

Evening stiffness

Question 8

RF correlates with all the following except:

a. The severity of the disease in general
b. The presence of nodules
c. Other organ system involvement (i.e., vasculitis)
d. The age of the patient

Answer 8

The age of the patient

Question 9

In RA, vascular and parenchymal lesions suggest that lesions result from injury induced by immune complexes, especially those containing antibodies to:

Answer 9

IgG

Question 10

Serum complement levels are usually _______ in patients with rheumatoid arthritis.

Answer 10

Normal

Question 11

In the RF agglutination procedure, a false-positive result may
be observed in a serum specimen because of:

Answer 11

Hemolysis

Question 12

In rapid testing for rheumatoid factor, biological false-positive results can be caused by a variety of disorders including:

Answer 12

Hepatitis

AND/OR

Systemic lupus erythematosus

Question 13

Criteria for the diagnosis of rheumatoid arthritis include:

Answer 13

Morning stiffness

AND

Rheumatoid nodules

AND

Radiographic changes