Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immuno > EXAM 3 > Flashcards

EXAM 3 Flashcards

1
Q

Typical lab results typically seen in lymphoid chronic thyroiditis are:

A

Increased TSH, decreased T3 and T4, anti-TPO antibodies present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

This type of ANA pattern characterizes anti-DNA nucleoprotein antibodies

A

Homogeneous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Autoimmune hepatitis is most common in:

A

Young women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

T/F: B cells undergo a second process of selection during their maturation.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

T/F: The thyroid is responsible for deleting autoreactive T cells that have the potential to cause autoimmune disease.

A

False

(Thymus is!!)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

T/F: Tolerance is a lack of immune response to self antigens.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which are the pathways for T cell tolerance

A
  • Clonal abortion
  • Functional Deletion
  • T cell suppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the pathways of B cell tolerance

A
  • Clonal abortion
  • Functional deletion
  • Clonal exhaustion
  • Antibody forming cell blockade
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What stage of autoimmune disease is associated with active disease state.

A

Propagation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which is not an example of an organ-specific autoimmune disorder.

  • Rheumatoid arthritis
  • Type 1 diabetes
  • Multiple sclerosis
  • Thyroid disease
A

Rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antinuclear antibodies include all but:

  • DNA
  • Histone
  • Nonhistone protein antibodies
  • Antihistamine antibodies
A

Antihistamine antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

This is a chronic, multisystem disease that causes thickening of the skin.

A

Progressive systemic sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

This disorder is linked to exposure to L-tryptophan.

A

Eosinophilia-myalgia syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The presence of this antibody doesn’t exclude or confirm Hashimotos, can be positive in Graves patients, thyroid cancers, and subacute thyroiditis.

A

Thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Pernicious anemia is caused by a deficiency of:

A

Vitamin B12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Polyclonal gammopathies can be exhibited as a secondary manifestation of all of the following except:

  • Chronic infection
  • Chronic liver disease
  • Multiple myeloma
  • Rheumatoid connective disease
A

Multiple myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which cytokine is essential for survival and growth of myeloma cells.

A

IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which of the following is not true of Sjogren syndrome?

A

Hypogammaglobulinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Warm-reactive autoantibodies react at ______temperature.

A

37 C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

This type of ANA pattern is detected against anti-RNP and anti-Sm.

A

Speckled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

This is the most common demyelinating disease of the CNS

A

Multiple Sclerosis

22
Q

One of the most frequent causes of drug-induced lupus is:

A

Procainamide hydrochloride

23
Q

SLE is more common in:

A

Adolescent through middle-aged women

24
Q

Patients with SLE typically manifest:

A

Butterfly rash over the bridge of the nose

25
Rheumatoid arthritis is known to be caused by genetic issues.
False
26
Arrange the steps of pathogenesis of rheumatoid arthritis is the correct order: - Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process - Initiation of synovitis by the primary causative factor - Subsequent immunologic events that perpetuate the initial inflammatory reaction
1) Initiation of synovitis by the primary causative factor 2) Subsequent immunologic events that perpetuate the initial inflammatory reaction 3) Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
27
Which is the least common of the major immunoglobulin classes of rheumatoid factor.
IgA
28
Development of autoantibodies in SLE is due to defective ______tolerance for self antigens.
B cell
29
Which of the following is not associated with SLE. - Butterfly rash - Psychosis - Inflammation - Hives
Hives
30
Bence Jones (BJ) proteins are soluble at room temperature and become insoluble (precipitate) near:
60 C (soluble at 20 // dissolve at 100)
31
Which cell type(s) is/are involved in the pathogenesis of SLE?
- B lymphs - T lymphs - Dendritic Cells
32
Discoid lupus is always limited to the ______.
Skin
33
T/F: The presence of lupus anticoagulants increases the risk of bleeding.
False
34
________ antibodies are the only autoantibodies that may be used to monitor disease activity of SLE.
Anti-dsDNA
35
T/F: ANAs can be used to confirm SLE.
False
36
This type of ANA pattern is highly selective for CREST variant of systemic sclerosis.
Centromere
37
Which type of cells are responsible for initiating the immune response to islet cells in Type 1 Diabetes
CD4+ T cells
38
Which test is most specific for rheumatoid arthritis?
anti-CCPs
39
To be diagnosed with Juvenile Idiopathic Arthritis you need to be under the age of _____.
16 years
40
What is the most frequent cause of death in a patient with multiple myeloma?
Infectious diseases
41
Patients with multiple myeloma have defects in:
- Humoral immunity - Synthesis of normal immunoglobulins
42
Cryoglobulins are proteins that precipitate or gel at:
0 C
43
Most patients with multiple myeloma manifest:
Bone pain
44
Patients with Waldenstrom macroglobulinemia exhibit abnormally large amounts of:
IgM
45
Monoclonal gammopathy of undetermined significance (MGUS) represents a:
- Monoclonal protein in patients with no features of multiple myeloma or related malignant disorders - Disorder that can evolve into a malignant monoclonal gammopathy - Serum monoclonal protein concentration less than 3 g/dL
46
MGUS is characterized by all of the following except: - Less than 10% plasma cells in the bone marrow - Presence of lytic bone lesions - Anemia - Hypercalcemia
Presence of lytic bone lesions
47
Light chain disease represents about ________ of monoclonal gammopathies.
10-15%
48
This figure represents the serum electrophoresis of a patient with:
Multiple myeloma
49
Which is the most common immunoglobulin affected with multiple myeloma?
IgG
50
In light chain disease, only _______ and _______ monoclonal light chains, or BJ proteins are produced
kappa, lambda

Immuno (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions