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Immuno > EXAM 3 > Flashcards

EXAM 3 Flashcards

1
Q

Typical lab results typically seen in lymphoid chronic thyroiditis are:

A

Increased TSH, decreased T3 and T4, anti-TPO antibodies present

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2
Q

This type of ANA pattern characterizes anti-DNA nucleoprotein antibodies

A

Homogeneous

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3
Q

Autoimmune hepatitis is most common in:

A

Young women

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4
Q

T/F: B cells undergo a second process of selection during their maturation.

A

True

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5
Q

T/F: The thyroid is responsible for deleting autoreactive T cells that have the potential to cause autoimmune disease.

A

False

(Thymus is!!)

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6
Q

T/F: Tolerance is a lack of immune response to self antigens.

A

True

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7
Q

Which are the pathways for T cell tolerance

A
  • Clonal abortion
  • Functional Deletion
  • T cell suppression
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8
Q

What are the pathways of B cell tolerance

A
  • Clonal abortion
  • Functional deletion
  • Clonal exhaustion
  • Antibody forming cell blockade
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9
Q

What stage of autoimmune disease is associated with active disease state.

A

Propagation

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10
Q

Which is not an example of an organ-specific autoimmune disorder.

  • Rheumatoid arthritis
  • Type 1 diabetes
  • Multiple sclerosis
  • Thyroid disease
A

Rheumatoid arthritis

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11
Q

Antinuclear antibodies include all but:

  • DNA
  • Histone
  • Nonhistone protein antibodies
  • Antihistamine antibodies
A

Antihistamine antibodies

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12
Q

This is a chronic, multisystem disease that causes thickening of the skin.

A

Progressive systemic sclerosis

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13
Q

This disorder is linked to exposure to L-tryptophan.

A

Eosinophilia-myalgia syndrome

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14
Q

The presence of this antibody doesn’t exclude or confirm Hashimotos, can be positive in Graves patients, thyroid cancers, and subacute thyroiditis.

A

Thyroglobulin

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15
Q

Pernicious anemia is caused by a deficiency of:

A

Vitamin B12

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16
Q

Polyclonal gammopathies can be exhibited as a secondary manifestation of all of the following except:

  • Chronic infection
  • Chronic liver disease
  • Multiple myeloma
  • Rheumatoid connective disease
A

Multiple myeloma

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17
Q

Which cytokine is essential for survival and growth of myeloma cells.

A

IL-6

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18
Q

Which of the following is not true of Sjogren syndrome?

A

Hypogammaglobulinemia

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19
Q

Warm-reactive autoantibodies react at ______temperature.

A

37 C

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20
Q

This type of ANA pattern is detected against anti-RNP and anti-Sm.

A

Speckled

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21
Q

This is the most common demyelinating disease of the CNS

A

Multiple Sclerosis

22
Q

One of the most frequent causes of drug-induced lupus is:

A

Procainamide hydrochloride

23
Q

SLE is more common in:

A

Adolescent through middle-aged women

24
Q

Patients with SLE typically manifest:

A

Butterfly rash over the bridge of the nose

25
Q

Rheumatoid arthritis is known to be caused by genetic issues.

A

False

26
Q

Arrange the steps of pathogenesis of rheumatoid arthritis is the correct order:

  • Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
  • Initiation of synovitis by the primary causative factor
  • Subsequent immunologic events that perpetuate the initial inflammatory reaction
A

1) Initiation of synovitis by the primary causative factor

2) Subsequent immunologic events that perpetuate the initial inflammatory reaction

3) Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process

27
Q

Which is the least common of the major immunoglobulin classes of rheumatoid factor.

A

IgA

28
Q

Development of autoantibodies in SLE is due to defective ______tolerance for self antigens.

A

B cell

29
Q

Which of the following is not associated with SLE.

  • Butterfly rash
  • Psychosis
  • Inflammation
  • Hives
A

Hives

30
Q

Bence Jones (BJ) proteins are soluble at room temperature and become insoluble (precipitate) near:

A

60 C

(soluble at 20 // dissolve at 100)

31
Q

Which cell type(s) is/are involved in the pathogenesis of SLE?

A
  • B lymphs
  • T lymphs
  • Dendritic Cells
32
Q

Discoid lupus is always limited to the ______.

A

Skin

33
Q

T/F: The presence of lupus anticoagulants increases the risk of bleeding.

A

False

34
Q

________ antibodies are the only autoantibodies that may be used to monitor disease activity of SLE.

A

Anti-dsDNA

35
Q

T/F: ANAs can be used to confirm SLE.

A

False

36
Q

This type of ANA pattern is highly selective for CREST variant of systemic sclerosis.

A

Centromere

37
Q

Which type of cells are responsible for initiating the immune response to islet cells in Type 1 Diabetes

A

CD4+ T cells

38
Q

Which test is most specific for rheumatoid arthritis?

A

anti-CCPs

39
Q

To be diagnosed with Juvenile Idiopathic Arthritis you need to be under the age of _____.

A

16 years

40
Q

What is the most frequent cause of death in a patient with multiple myeloma?

A

Infectious diseases

41
Q

Patients with multiple myeloma have defects in:

A
  • Humoral immunity
  • Synthesis of normal immunoglobulins
42
Q

Cryoglobulins are proteins that precipitate or gel at:

A

0 C

43
Q

Most patients with multiple myeloma manifest:

A

Bone pain

44
Q

Patients with Waldenstrom macroglobulinemia exhibit abnormally large amounts of:

A

IgM

45
Q

Monoclonal gammopathy of undetermined significance (MGUS) represents a:

A
  • Monoclonal protein in patients with no features of multiple myeloma or related malignant disorders
  • Disorder that can evolve into a malignant monoclonal gammopathy
  • Serum monoclonal protein concentration less than 3 g/dL
46
Q

MGUS is characterized by all of the following except:

  • Less than 10% plasma cells in the bone marrow
  • Presence of lytic bone lesions
  • Anemia
  • Hypercalcemia
A

Presence of lytic bone lesions

47
Q

Light chain disease represents about ________ of monoclonal gammopathies.

A

10-15%

48
Q

This figure represents the serum electrophoresis of a patient with:

A

Multiple myeloma

49
Q

Which is the most common immunoglobulin affected with multiple myeloma?

A

IgG

50
Q

In light chain disease, only _______ and _______ monoclonal light chains, or BJ proteins are produced

A

kappa, lambda

Immuno (23 decks)

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