EXAM 3 Flashcards
Typical lab results typically seen in lymphoid chronic thyroiditis are:
Increased TSH, decreased T3 and T4, anti-TPO antibodies present
This type of ANA pattern characterizes anti-DNA nucleoprotein antibodies
Homogeneous
Autoimmune hepatitis is most common in:
Young women
T/F: B cells undergo a second process of selection during their maturation.
True
T/F: The thyroid is responsible for deleting autoreactive T cells that have the potential to cause autoimmune disease.
False
(Thymus is!!)
T/F: Tolerance is a lack of immune response to self antigens.
True
Which are the pathways for T cell tolerance
- Clonal abortion
- Functional Deletion
- T cell suppression
What are the pathways of B cell tolerance
- Clonal abortion
- Functional deletion
- Clonal exhaustion
- Antibody forming cell blockade
What stage of autoimmune disease is associated with active disease state.
Propagation
Which is not an example of an organ-specific autoimmune disorder.
- Rheumatoid arthritis
- Type 1 diabetes
- Multiple sclerosis
- Thyroid disease
Rheumatoid arthritis
Antinuclear antibodies include all but:
- DNA
- Histone
- Nonhistone protein antibodies
- Antihistamine antibodies
Antihistamine antibodies
This is a chronic, multisystem disease that causes thickening of the skin.
Progressive systemic sclerosis
This disorder is linked to exposure to L-tryptophan.
Eosinophilia-myalgia syndrome
The presence of this antibody doesn’t exclude or confirm Hashimotos, can be positive in Graves patients, thyroid cancers, and subacute thyroiditis.
Thyroglobulin
Pernicious anemia is caused by a deficiency of:
Vitamin B12
Polyclonal gammopathies can be exhibited as a secondary manifestation of all of the following except:
- Chronic infection
- Chronic liver disease
- Multiple myeloma
- Rheumatoid connective disease
Multiple myeloma
Which cytokine is essential for survival and growth of myeloma cells.
IL-6
Which of the following is not true of Sjogren syndrome?
Hypogammaglobulinemia
Warm-reactive autoantibodies react at ______temperature.
37 C
This type of ANA pattern is detected against anti-RNP and anti-Sm.
Speckled
This is the most common demyelinating disease of the CNS
Multiple Sclerosis
One of the most frequent causes of drug-induced lupus is:
Procainamide hydrochloride
SLE is more common in:
Adolescent through middle-aged women
Patients with SLE typically manifest:
Butterfly rash over the bridge of the nose
Rheumatoid arthritis is known to be caused by genetic issues.
False
Arrange the steps of pathogenesis of rheumatoid arthritis is the correct order:
- Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
- Initiation of synovitis by the primary causative factor
- Subsequent immunologic events that perpetuate the initial inflammatory reaction
1) Initiation of synovitis by the primary causative factor
2) Subsequent immunologic events that perpetuate the initial inflammatory reaction
3) Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
Which is the least common of the major immunoglobulin classes of rheumatoid factor.
IgA
Development of autoantibodies in SLE is due to defective ______tolerance for self antigens.
B cell
Which of the following is not associated with SLE.
- Butterfly rash
- Psychosis
- Inflammation
- Hives
Hives
Bence Jones (BJ) proteins are soluble at room temperature and become insoluble (precipitate) near:
60 C
(soluble at 20 // dissolve at 100)
Which cell type(s) is/are involved in the pathogenesis of SLE?
- B lymphs
- T lymphs
- Dendritic Cells
Discoid lupus is always limited to the ______.
Skin
T/F: The presence of lupus anticoagulants increases the risk of bleeding.
False
________ antibodies are the only autoantibodies that may be used to monitor disease activity of SLE.
Anti-dsDNA
T/F: ANAs can be used to confirm SLE.
False
This type of ANA pattern is highly selective for CREST variant of systemic sclerosis.
Centromere
Which type of cells are responsible for initiating the immune response to islet cells in Type 1 Diabetes
CD4+ T cells
Which test is most specific for rheumatoid arthritis?
anti-CCPs
To be diagnosed with Juvenile Idiopathic Arthritis you need to be under the age of _____.
16 years
What is the most frequent cause of death in a patient with multiple myeloma?
Infectious diseases
Patients with multiple myeloma have defects in:
- Humoral immunity
- Synthesis of normal immunoglobulins
Cryoglobulins are proteins that precipitate or gel at:
0 C
Most patients with multiple myeloma manifest:
Bone pain
Patients with Waldenstrom macroglobulinemia exhibit abnormally large amounts of:
IgM
Monoclonal gammopathy of undetermined significance (MGUS) represents a:
- Monoclonal protein in patients with no features of multiple myeloma or related malignant disorders
- Disorder that can evolve into a malignant monoclonal gammopathy
- Serum monoclonal protein concentration less than 3 g/dL
MGUS is characterized by all of the following except:
- Less than 10% plasma cells in the bone marrow
- Presence of lytic bone lesions
- Anemia
- Hypercalcemia
Presence of lytic bone lesions
Light chain disease represents about ________ of monoclonal gammopathies.
10-15%
This figure represents the serum electrophoresis of a patient with:
Multiple myeloma
Which is the most common immunoglobulin affected with multiple myeloma?
IgG
In light chain disease, only _______ and _______ monoclonal light chains, or BJ proteins are produced
kappa, lambda
