CH 23 - Systemic Lupus Erythematosus

Question 1

SLE is more common in:

Answer 1

Adolescent through middle-aged women

Question 2

One of the most potent inducers of abnormalities and clinical manifestations of SLE is:

Answer 2

Procainamide hydrochloride

Question 3

The cellular aberrations in SLE include:

Answer 3

Deficiency of suppressor T cell function

AND

Hyperproduction of helper T cells

Question 4

The principal demonstrable antibody in SLE is antibody to:

Answer 4

Nuclear antigen

Question 5

The sites of immune complex deposition in SLE are influenced by all the following factors except:

a. Molecular size
b. Molecular configuration
c. Immune complex specificity
d. Immunoglobulin class

Answer 5

Immune complex specificity

Question 6

Renal disease secondary to SLE can be assessed by:

Answer 6

Antibody to native dsDNA

AND

Levels of C3 and C4

AND

Levels of ANA

Question 7

SLE is a classic model of autoimmune disease and is a(n):

Answer 7

Abnormality of the joints

AND

Systemic rheumatoid disorder

AND

Abnormality of connective tissue

Question 8

The overall incidence of SLE has an increased frequency among:

Answer 8

African Americans

AND

Native Americans

AND

Puerto Ricans

Question 9

Patients with SLE characteristically manifest:

Answer 9

Butterfly rash over the bridge of the nose

Question 10

Laboratory features of SLE include:

Answer 10

The presence of ANAs

AND

Circulating anticoagulant and immune complexes

AND

Decreased levels of complement

Question 11

Laboratory procedures that are helpful in assessing renal disease include:

Answer 11

Antibody to double-stranded DNA

AND

Levels of C3 and C4

AND

Cryoglobulin assay

Question 12

T/F: Antinuclear antibodies (ANAs) are always indicative of SLE.

Answer 12

FALSE