Exam 2: Pharmacokinetics

Question 1

The mathematical description of the plasma concentration- time course

Answer 1

Pharmacokinetics

Question 2

What are the 4 components of a dosage regimen?

Answer 2

1. Dosage
2. Route of admin
3. Frequency
4. Druation of admin

Question 3

The optimum dosage regimin has what 3 qualities?

Answer 3

1. Effective
2. Non toxic
3. W/O prolonged drug residues in tissues of food an.

Question 4

The time to peak plasma conc.

Answer 4

Rate of absorption (tmax)

Question 5

Measured by systemic bioavailablility (F%)

Answer 5

Extent of absorption

Question 6

The fraction of the dose which reaches the systemic circ. intact

Answer 6

Systemic bioavailability

Question 7

what is the one compartment model?

Answer 7

all tissues which the drug penetrates behaves as if they were in ready equilibrium with blood

Question 8

What is the two compartment model?

Answer 8

drug moves in the body as if 2 commpartment

Question 9

What is the most common compartment model?

Answer 9

2 compartment

Question 10

Estimated by the distribution phase half time in the two compartment model

Answer 10

Rate of Distribution

Question 11

Measured by the apparent volume of distribution (Vd)

Answer 11

Extent of distribution

Question 12

The volume of fluid which would be required to contain the amount of the drug in the body if it were uniformly distributed, and the conc. in that fluid was equal to te conc. in the plasma

Answer 12

(Vd) Apparent volume of distribution

Question 13

The amt. of drug in the body

Answer 13

Dose IV

Question 14

What does it mean when a drug has a Vd <1L/kg

Answer 14

Drug has limited distribution (stays in plasma)

Question 15

What does it mean when a drug has a Vd =1L/kg?

Answer 15

Drug has a wide distribution

Question 16

What does it mean when a drug has a Vd> 1L/kg

Answer 16

Drug has a very wide distribution

Question 17

How is elimination measured

Answer 17

half life or total body clearance

Question 18

The time required for the body to eliminate one- half of the drug

Answer 18

half life (t1/2)

Question 19

Elimination of most drugs follows what order kinetics

Answer 19

First

Question 20

Elimination of a constant fraction per time of the drug

Answer 20

First order kinetics

Question 21

Elimination = proportional to the conc. of drug

Answer 21

First order kinetics

Question 22

First order kinetics is considered a ___ process

Answer 22

Linear

Question 23

Constant amt. of drug is eliminated per unit time

Answer 23

Zero order kinetics

Question 24

When does zero order kinetics occur?

Answer 24

when saturated

Question 25

The plasma conc. of drug when the maintenance rate of drug admin. is qual to the rate of elimination

Answer 25

Steady- State plasma conc.

Question 26

The rate of drug elimination from the body, by all routes, relative to the conc. of drug in plasma

Answer 26

Total body clearance (clB)

Question 27

The volume of plasma cleared of the drug per unit time

Answer 27

Plasma clearance (CLp)

Question 28

The fraction of the drug removed from the perfusing blood by an organ

Answer 28

Extraction ratio