Exam 2: Immunosuppressors and Chemotherapy drugs Flashcards
What is the goal of Chemotherapy drugs?
Kill unwanted cells
What 2 categories of drugs are used in Anti-inflammatory therapy?
NSAIDs
Glucocorticoids
The first-line for general immunosuppression is usually high dose of _____
glucocorticoids
What is the general MOA of glucocorticoids?
inhibit production of chemotactic factors and inhibit secretionof proteolytic enzymes
What do antimetabolites do?
impair nucleic acid synthesis, particularly in rapidly dividing cells
What are the 3 Antimetabolites
- Azathioprine
- Mycophenolate mofetil
- Leflunomi1de
What is the MOA of Cyclosporine?
T-cell inhibitor
What drug do you use to treat canine keratoconjunctivitis sicca (KCS)
Cyclosporine
What drug can you give to tx perianal fistulas
Cyclosporine
What are the major side effects of Cyclosporine use?
- Toxicity
- GI upset
- Gingival proliferation
Some of the less toxic chemotherapy drugs are sometimes used to manage _____.
immune- mediate diseases
What are the 3 most common adverse effects of Chemo drugs?
- Toxicity
- Drug resistance
- Acute tumor lysis syndrome
What is Acute tumor lysis syndrome?
masssive killing of cancer cells leading to severe systemic dz
Conventional chemotherapy dosing uses ________ to achieve the gratest efficacy
Maximum tolerated dose
What is metronomic chemotherapy?
Lower doses of drugs are given over longer periods of time
