Exam 1: Disposition of Drugs Flashcards
Study of the movement of drugs in the body across biological membranes from the time of absorption until elimination?
Pharmacokinetics
What are the 4 stages of drug disposition?
- Absorption
- Distribution
- Biotransformation
- Excretion
Factors affecting disposition of the drug:
- biological cell memb
- conc. gradient
- Pump mech.
- site of admin.
- Total body water
- plasma prtoein binding
- disease
List 4 properties of the biological cell memb.
- phospholipid bilayer
- memb. proteins and carbohydrates
- cell junctions
- aqueous pores
List 4 mechanisms of transport across cell membranes:
- Passive diffusion
- Facilitated diffusion
- Active transport
- Pinocytosis
Type of transport that does not require energy
Passive diffusion
What are the 3 mechanisms of passive diffusion
- transmembrane
- paracellular
- simple diffusion
Movement by passive diffusion through aqueous protein channels in the cell memb.
Transmembrane
Movement via filtration through intracellular aqueous pores
Paracellular
Movement through lipid memb.
Simple diffusion
The majority of drugs move through the body via _____
Simple diffusion
T/F Energy is not required for facilitated diffusion
T
T/F Active transport needs both a carrier and ATP
T
T/F Active transport moves drugs from high conc. to low
F. low to high
Na+/K+ ATPase transport pump is an example of primary or secondary active transport?
Primary