Exam 1: Disposition of Drugs Flashcards

1
Q

Study of the movement of drugs in the body across biological membranes from the time of absorption until elimination?

A

Pharmacokinetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 4 stages of drug disposition?

A
  1. Absorption
  2. Distribution
  3. Biotransformation
  4. Excretion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Factors affecting disposition of the drug:

A
  1. biological cell memb
  2. conc. gradient
  3. Pump mech.
  4. site of admin.
  5. Total body water
  6. plasma prtoein binding
  7. disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

List 4 properties of the biological cell memb.

A
  1. phospholipid bilayer
  2. memb. proteins and carbohydrates
  3. cell junctions
  4. aqueous pores
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

List 4 mechanisms of transport across cell membranes:

A
  1. Passive diffusion
  2. Facilitated diffusion
  3. Active transport
  4. Pinocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Type of transport that does not require energy

A

Passive diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the 3 mechanisms of passive diffusion

A
  1. transmembrane
  2. paracellular
  3. simple diffusion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Movement by passive diffusion through aqueous protein channels in the cell memb.

A

Transmembrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Movement via filtration through intracellular aqueous pores

A

Paracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Movement through lipid memb.

A

Simple diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The majority of drugs move through the body via _____

A

Simple diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F Energy is not required for facilitated diffusion

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

T/F Active transport needs both a carrier and ATP

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T/F Active transport moves drugs from high conc. to low

A

F. low to high

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Na+/K+ ATPase transport pump is an example of primary or secondary active transport?

A

Primary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Na dependent glucose transporters are examples of primary or secondary active transport

A

Secondary

17
Q

Specific type of endocytosis where cell engulfs the drug molecules dissolved in water “cell drinking”

A

Pinocytosis

18
Q

T/F Facilitated diffusion moves down the conc. gradient?

A

T

19
Q

T/F Facilitated diffusion requires a carrier and energy

A

F no energy

20
Q

T/F Facilitated diffusion is saturable

A

T

21
Q

T/F in facilitated diffusion the substance can be transported in or out of cell

A

T

22
Q

T/F passive diffusion moves down the concentration gradient

A

T

23
Q

T/F Passive diffusion requires energy

A

F

24
Q

T/F Facilitated diffusion is the most common form of transport

A

F. Passive diffusion

25
Q

T/F Active transport moves uphil from llow to high conc.

A

T

26
Q

T/F Active transport uses symporters and anitporters

A

T

27
Q

T/F active transport is not saturable

A

F

28
Q

T/F Pinocytosis can be toxic

A

t

29
Q

T/F Pinocytosis does not work if drug is dissolved in water

A

F. must be

30
Q

What are the 3 factors that affect simple diffusion

A
  1. Conc. gradient
  2. Lipid solubility
  3. Degree of drug ionization
31
Q

T/F. The higher the lipid solubility of the drug the faster crossing the cell memb

A

T

32
Q

T/F. membranes are more permeable to ionized forms of drugs

A

F. non ionized

33
Q

T/F Drugs cros biological membranes in non ionized forms

A

T

34
Q

T/F rate of diffusion depends on degree ofionization

A

T

35
Q

What 3 things does degree of ionization depend on?

A
  1. pH of the drug
  2. pKa of the drug
  3. pH of environment in vivo
36
Q

T/F weakly basic drugs are more ionized in alkaline solutions

A

F. acidic solutions

37
Q

Equal to the pH of the mediam at which the dissolved drug is 50% ionized and 50% not

A

pKa

38
Q

Henderson Hasselbach equation can be used to determine the ____

A

degree of ionization