Exam 1: Excretion of Drugs

Question 1

The removal or clearance of the drug from the body

Answer 1

Excretion of drugs

Question 2

What is the most common route of drug excretion

Answer 2

Renal

Question 3

Renal excretion is dependent on 3 factors:

Answer 3

1. GFR
2. Active tubular secretion
3. Passive tubular secretion

Question 4

What are the 4 factors affecting glomerular filtration

Answer 4

1. GFR
2. Molecular size
3. Molecular charge
4. Plasma protein binding

Question 5

T/F only bound drugs are freely filteralbe

Answer 5

F. unbound

Question 6

Transport endogenous organic bases and basic drugs

Answer 6

Organic cation transporters (OTC)

Question 7

Transports endogenous organic acids and acidic drugs

Answer 7

Organic Anion transporter (OAT)

Question 8

T/F. The more ionized the drug, the more reabsorption occurs and the more the drug is excreted

Answer 8

F. less reabsorption

Question 9

What are the 6 factors that affects total renal excretion

Answer 9

1. Liver, kidney, cardiac Dz
2. Age
3. Urine pH modifiers
4. Fluid therapy
5. Plasma protein binding (PPB)
6. Dose and rate of drug absorption

Question 10

conjugates of lipophilic compounds excreted in bile can be hydrolyzed in the intestines which converts them back to lipid soluble free drugs so they can reabsorb

Answer 10

Enterohepatic recirculation

Question 11

T/F. Enterohepatic recirculation dec. the 1/2 life of a drug

Answer 11

F. prolongs the life

Question 12

acidic/basic drugs are excreted in milk

Answer 12

Basic