Exam 1: Absorption of Drugs Flashcards
The Transfer of the drug from the site of admin. to systemic circ.
Absorption
What are the factors related to the drug affect absorption?
- molecular size
- lipid solubility
- Degree of ionization
- Dissolution in water
- conc. at absorptive site
- route of admin
What are factors affecting absorption related to the animal
- blood flow
- absorptive SA
- CT
- Species
- Individual
T/F oral absorption of drugs is faster in liquid drugs than solid drugs
T
Rearrange the following based on Rate of absorption:
Inhalation, IM, SQ, Enteral, Sublingual
Inhalation> Sub L> IM> SQ> Enteral
T/F the presence of CT typically dec. absorption
T
Which part of the GIT is the main site of absorption for enterally administered drugs
upper part of sm. intestine
T/F the rate of absorption can depend on the rate of gastric emptying
T
What is the rate limiting step for oral absorption
Dissolution, because drugs given orally must disintegrate before they can dissolve, and must dissolve before they can be absorbed
In regards to dissolution which is faster?
a. Liquid
b. Gel
c. Table
d. Coated tablet
a. Liquid
What is First-Pass Effect?
Drugs absorbed from GIT and distributed first to the liver for metabolism
T/F Drugs with high first pass metabolism will have greater distribution
F. less distribution
T/F some drugs will be etabolized before distribution to other tissues
t
