Exam 1: Distribution

Question 1

The transfer of the drug from the site of admin to the systemic circ.

Answer 1

Absorption

Question 2

The transport of drugs from the plasma to the tissue

Answer 2

Distribution

Question 3

List some factors related to the drug that affect distribution

Answer 3

1. lipid solubility
2. degree of ionization
3. Conc. gradient
4. Plasma protein binding
5. Affinity for certain tissues

Question 4

List some factors related to the animal that affects drug distribution

Answer 4

1. BF
2. Species
3. Plasma protein binding
4. Tissue barriers

Question 5

Acidic drugs mainly bind to ____ in plasma

Answer 5

Albumin

Question 6

Basic drugs mainly bind to ____ in plasma

Answer 6

Alpha- glycoproteins and lipoproteins

Question 7

T/F. Plasma protein binding is generally irreversible?

Answer 7

F. reversible

Question 8

T/F. only bound drugs are biologically active

Answer 8

F. only free/unbound drugs are biologically active

Question 9

T/F. Plasma protein bound drugs cannot be distributed into the tissues, metabolized, or excreted by the kidney

Answer 9

t

Question 10

T/F. plasma protein binding prolongs the 1/2 life of the drug

Answer 10

T

Question 11

The rate of plasma protein binding depends mainly on the _____

Answer 11

amt of the drug

Question 12

T/F. drugs can compete for the same binding site

Answer 12

t

Question 13

List the 5 highly perfused tissues of the body?

Answer 13

Brain
Liver
Kidney
Glands
Heart

Question 14

List the 2 poorly perfused tissues of the body

Answer 14

1. Bone

2. Adipose

Question 15

What are the 3 factors that can alter BF?

Answer 15

1. Physoplogic factors (Stress)
2. Drugs
3. Disease

Question 16

List 5 physiological factors that affect the BBB.

Answer 16

1. Inflammation
2. Allergic rxn.
3. Severe hypotension or hypoxia
4. Organic solvents
5. Heavy metals

Question 17

The movement of drugs from the tissues back to the bloodstream

Answer 17

Redistribution of drugs