Exam 1: Pharmacology Factors Modifying Drug dose & Response

Question 1

A genetically determined and unpredictable individual drug sensitivity

Answer 1

Idiosyncratic Drug Reaction

Question 2

T/F Idiosyncratic Drug reactions are dose-dependent

Answer 2

F.

Question 3

Allergic Drug reaction

Answer 3

Drug hypersensitivity Reaction

Question 4

T/F Prior exposure is necessary for drug hypersensitivity rxn.

Answer 4

T

Question 5

Cant metabolize most drugs normally, dec. drug metabolism

Answer 5

hepatic dysfunction

Question 6

cant excrete most drugs via the kidney and into the urine normally, dec. drug excretion

Answer 6

Renal insufficiency

Question 7

Cant pump drugs to site of action, metabolism, or excretion normally, dec. renal excretion

Answer 7

congestive heart failure (CHF)

Question 8

An unusual resistance to ordinary drug dose

Answer 8

Drug Tolerance

Question 9

What are the 3 forms of dug tolerance?

Answer 9

1. Natural tolerance
2. Acquired Tolerance
3. Cross- tolerance
4. Tachyphylaxis

Question 10

What is an example of natural tolerance?

Answer 10

ruminants tolerant ot barbiturates

Question 11

What are 3 types of Acquired tolerance?

Answer 11

1. Enzyme induction
2. Inc. Excretion
3. Recptor down regulation

Question 12

Acute acquired tolerance where a diff. drug is needed to achieve a desired effect, no use giving the same drug

Answer 12

Tachyphylaxis

Question 13

Occurs when rate of elimination is slower than rate of absorption

Answer 13

Drug Accumulation

Question 14

The administration of drugs concurrently or sequentially

Answer 14

Drug-Drug interactions

Question 15

What are the 4 types of Drug-Drug Interactions?

Answer 15

1. Summation
2. Potentiation
3. Synergism
4. Antagonism

Question 16

Type of drug interaction where you give another drug with a different action and there is an intensification of the effects.

Answer 16

Potentiation

Question 17

Type of drug interaction where you give another drug with the same action which causes exaggeration of effects

Answer 17

Synergism

Question 18

Type of drug interaction that is the sum of the effects of the drugs

Answer 18

Summation

Question 19

Type of drug interaction where one drug dec. the effects of the other

Answer 19

Antagonism

Question 20

What are the 2 types of drug incompatibility

Answer 20

1. physical

2. chemical