Exam #2: Cartilage Flashcards

1
Q

Hyaline Cartilage

A
  • Most common type of cartilage
  • “Glassy” appearance
  • Fine & delicate collagen fibrils
  • Also called articular cartilage; allows free movement between articulating bones
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2
Q

Elastic Cartilage

A
  • Collagen & Elastic fibers
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3
Q

Fibrocartilage

A
  • Thick bundles of collagen
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4
Q

Where is Hyaline (articular) cartilage found?

A
  • Where it maintains a lumen: Trachea, Nostrils, Bronchi, Larynx
  • Articular surface of bone: Femur, Costochondral Joints, Sternocostal Joints
  • Epiphyseal Plates
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5
Q

Mesenchyme

A

Embryonic connective tissue that has the potential to differentiate into different types of tissue

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6
Q

Chondroblast

A
  • Mesenchymal cells that retract their processes & become more rounded
  • Synthesize ECM
  • Monitor the ECM & synthesize as needed
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7
Q

Chondrocyte

A
  • A Chondroblast that has completely surrounded itself in ECM & undergoes division
  • Continue to synthesize ECM (Interstitial Growth)
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8
Q

Isogenous Groups

A

Genetically uniform cells that arise from one parent cell

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9
Q

Perichondrium

A
  • Membrane that surrounds cartilage
  • Maintains the fitness of cartilage
  • Derived from mesenchyme that has differentiated into fibroblasts
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10
Q

How many layers does the perichondrium have?

A

Two:

1) Outer
2) Inner

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11
Q

Outer Layer of the Perichondrium

A
  • Fibrous layer that is protective & supportive
  • Contains fibroblasts that synthesize collagen
  • Also contains blood vessels, lymphatic vessels, & nerves
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12
Q

Inner Layer of the Perichondrium

A
  • Cellular layer that allows for cartilage growth
  • Contains chondrogenic cells that become chondroblasts & later chondrocytes
  • NO blood vessels or nerves
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13
Q

Interstitial Growth

A

Growth/expansion from within cartilage

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14
Q

Appositional Growth

A

Growth from the surface of cartilage

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15
Q

In what two locations is cartilage not covered by perichondrium?

A

1) Articular surface of bone

2) Epiphyseal plates

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16
Q

When does interstitial growth occur?

A
  • Embryonically & prenatally

- At the articular surface of bone

17
Q

What type of cartilage growth is more common

A
  • Appositional

- Appositional growth occurs on the surface of existing cartilage throughout life

18
Q

Where are chondrogenic cells located?

A
  • Chondrification Center

- Inner Layer of Perichondrium

19
Q

What is in the matrix of hyaline cartilage?

A
  • Type II Collagen
  • Proteoglycans
  • Glycoproteins
  • Extracellular Fluid (which hydrate glycosaminoglycans)
20
Q

Proteoglycans of Hyaline Cartilage

A
  • Bottle brush morphology that contain a core protein & GAG (hydrated)
  • Hyaluronan/ Hyaluronic Acid
21
Q

What is the capsular matrix?

A

Matrix immediately surrounding each chondrocyte

Contents:

  • Proteoglycans
  • Glycoproteins
  • Hyaluronan
  • Type VI Collagen
22
Q

Territorial Matrix

A
  • Matrix father from the chondrocyte
  • Pale blue/pink color
  • Lower concentration of proteoglycans than capsular matrix
23
Q

Interterritorial Matrix

A
  • Matrix further out than the territorial matrix

- Paler blue because it contains a more dilute concentration of molecules (proteoglycans)

24
Q

Properties of Hyaline Cartilage

A
  • Avascular
  • NO nerve fibers
  • Matrix resists forces & compression between articular surfaces of bone
25
Q

Where is elastic cartilage found?

A
  • Auricle
  • Epiglottis
  • Auditory Tubes
26
Q

Characteristics of Elastic Cartilage

A
  • Larger chondrocytes than hyaline cartilage
  • Elastic fibers in territorial & interterritorial matrix
  • Yellow instead of blue appearance
27
Q

Fibrocartilage

A
  • Dense collagenous connective tissue

- Chondrocytes form columns squeezed between collagen bundles

28
Q

Where is fibrocartilage located?

A
  • Articular disc in TMJ
  • Intervertebral Discs
  • Pubic Symphysis
29
Q

Osteoarthritis

A
  • Degenerative Joint Disease
  • Articular surface of bone degenerates & exposes underlying bone
  • Caused by dehydration of glycosaminoglycans that happens with age