Escherichia Coli Flashcards

1
Q

What is the microbiome?

A

All genetic material within organisms in a niche (e.g. gut)

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2
Q

Describe E.coli

A

Gram negative
Rod shaped
Facultative anaerobes
Part of microbiome

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3
Q

How does e.coli obtain energy?

A

Oxidation/reduction of organic substances

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4
Q

What are the 2 types of E.coli?

A
Intestinal (caused by diarrhogenic E.coli)
Non intestinal (caused by non intestinal e. Coli)
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5
Q

What are types of intestinal E. coli?

A

Enterohaemorrhagic
Enterotoxigenic
Enterpathogenic
Anything with entero!

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6
Q

What are examples of non intestinal E. Coli?

A

Neonatal meningitis associated E. coli
Avian pathogenic
Mastitis E. coli
Unopathogenic

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7
Q

How do intestinal e. Coli cause diseases?

A

Enterotoxins damage enterocytes

Leads fo diarrhoea

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8
Q

What are shiga like toxins (STx)? What do they do?

A

Toxins carried by STEC (Shiga toxins e.coli)
Act on blood vessels to cause haemorrhage and kidney damage
Lead to oedema of face

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9
Q

What is a key virulence factor for enterohaemorrhagic E. coli and eneteropathogenic E. coli? What does it do?

A

LEE - locus of enterocyte effacement

Allows tight binding to the gut

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