Epilepsy, concussions, and MS Flashcards

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1
Q

Seizures

A

brief, sudden, excessive discharge of electrical activity in the brain

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2
Q

Provoked seizure

A

have a direct cause (head injury, non-epileptic infection, drugs)

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3
Q

Epileptic seizure

A

does not have an immediate cause

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4
Q

Psychogenic Non-epileptic seizures (PNES)

A

resemble seizures, but without abnormal brain electrical activity; caused by stress

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5
Q

Focal seizure

A

onset is localized to a specific region of the brain

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6
Q

Simple seizure

A

does not impair consciousness

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7
Q

Complex seizure

A

alters consciousness

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8
Q

Generalized tonic clonic “grand mal” seizure

A

tonic extension of extremities and trunk (20 seconds) clonic synchronous rhythmic muscle movements (45 seconds)

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9
Q

EEG

A

measures brain electrical activity to identify seizures
- has poor sensitivity for location, but high specificity for seizures when interictal epileptiform activity is present

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10
Q

epilepsy

A

a disorder characterized by at least 2 unprovoked seizures 24 hours apart.
-can start @young age or in adulthood
-when starting in adulthood, more PNES

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11
Q

Anti-epileptic drugs (AEDS)

A

effective in 70% of individuals
-side effects may impact cognition and mood
-if 3 fail, likelihood of control is low (called intractable/refractory epilepsy)

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12
Q

Resection surgery for epilepsy

A

removal source of seizures
-most common surgery for intractable
-PNES would not improve w/surgery

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13
Q

Disconnection surgery for epilepsy

A

disrupt pathways allowing seizure to spread

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14
Q

Implantation of medical devices for epilepsy

A

vagal nerve stimulator (VNS) or deep brain stimulation (DBS)

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15
Q

Status epilepticus

A

condition in which patient undergoes series of seizures without regaining consciousness
-damage caused by excessive glutamate release during seizure
-seizures last more than 5 mins

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16
Q

Traumatic Brain Injury (TBI)

A

alteration in brain function or other evidence of brain pathology caused by an external force

17
Q

Closed injury

A

non-penetrative, outside force impacts head, skull is not broken

18
Q

open injury

A

penetrative injury, results when skill is broken or fractured

19
Q

Primary injury

A

what we think of as the brain injury or the immediate cause (Fall or car accident)
-diffuse injury

20
Q

Secondary injury

A

occurs in the hours/days following the injury as the injury evolves
-intracranial pressure from hemorrhage, iatrogenic effects from treatment
-could be focused or diffuse

21
Q

Glasgow coma scale

A

used to rate how traumatic an injury is
-monitors eye opening responses, verbal responses, and motor responses

22
Q

GCS mild

A

13-15, less than one day of posttraumatic confusion, loss of con for less than 30 mins

23
Q

GCS moderate

A

9-12, 1-7days of posttraumatic confusion, loss of con for 30mins to less than 24 hours

24
Q

GCS severe

A

<9, more than 7 days of posttraumatic confusion, loss of con for more than 24 hours

25
Q

Mild TBI (concussion)

A

70-90%
-neurons dysfunctional, not destroyed
-full recovery w/in 7-39 days
less than 3% less than a month

26
Q

moderate/severe injury

A

destruction and sheering of white matter (diffuse axonal injury)
-most recovery occurs in 1st year, most rapidly in first 3-6 months
-plateau in 2 years

27
Q

Post concussion syndrome

A

presence of persistent subjective cognitive/emotional complaints more than 3 months after injury
-commonly occurs with comorbid psych distress
-does not correlate with injury severity variables
-can be ass w/ inadequate pain symptom management

28
Q

What predicts recovery from a moderate to severe TBI

A

force of trauma, brain functions affected, areas that aren’t affected, age and time of injury, other bodily injuries

29
Q

Multiple sclerosis

A

Progressive autoimmune disorder where immune system attacks oligodendrocytes in CNS
-degradation of myelin that occurs in MS leads to a breakdown in communication between neurons
-can form at any site w/in CNS
-symptoms depend on lesion location

30
Q

MS epidemology

A

peak onset b/t 20 and 40
-more common in women
-genetic factors contribute

31
Q

MS causes

A

Hypothesis: a viral infection primes a susceptible immune system for an abnormal reaction later in life
-may be a response to a chronic infection

32
Q

MS symptoms

A

vision loss, weakness, double vision, vertigo, fatigue, etc.

33
Q

MS characteristic (course)

A

defined by experiences of relapses and disease progression

34
Q

MS relapses

A

worse periods of neurological symptoms caused by acute inflammatory demyelination

35
Q

MS disease progression

A

individuals will experience progressive disability due to chronic demyelination, gliosis, and axonal loss overtime

36
Q

MS cognitive impairment

A

40-65%
-related do damaged or destroyed white matter tracks resulting in diffuse white matter changes
-Most often affected (processing speed, attention, learning, memory, exec functioning)

37
Q

MS psychosocial

A

unemployment, functional impairment (decreased participation in activities), mental illness