DMARDs (Adverse effects) Flashcards
Abatacept
Increased risk of infections
Hypersensitivity reactions (anaphylaxis)
Increased risk of lymphomas
Rituximab
Increased risk of infections
Hypersensitivity reactions
Tocilizumab
Increased risk of infections Headache Hypertension Hepatic enzyme elevation Hematologic toxicity GI perforation (In pt with diverticulitis or those using glucocorticoids)
TNF-alpha inhibitors
Increased risk of infections
Increased risk of HBV and latent tuberculosis reactivation
Increased risk of skin cancers and lymphoma
Increased risk of heart failure
Others: Infusion site reactions, alopecia, hypertrichosis, and increased risk of GI ulcers
IL-1 inhibitors
Increased risk of infections
Increased risk of HBV and latent tuberculosis reactivation
Increased risk of skin cancers and lymphoma
Others: Infusion site reactions, alopecia, hypertrichosis, and increased risk of GI ulcers
Ustekinumab, Secukinumab, and Belimumab
Increased risk of infections
Azathioprine
Bone marrow suppression
GI toxicity
Increased risk of infections and lymphoma
Chloroquine and hydroxychloroquine
Nausea, vomiting, retinal detachment and blindness, exacerbation of psoriasis and pruritis
Cyclophosphamide
Pancytopenia Hemorrhagic cystitis Cardiotoxicity Electrolyte imbalance GI toxicity
Cyclosporine and Tacrolimus
Nephrotoxicity Hypertension, Hepatotoxicity Hirsituism Hematologic toxicity High doses: Cardio and neurotoxic, and sterility. Increased risk of bladder cancer (rare)
Leflunomide
Diarrhea, Elevated liver enzymes Mild alopecia Weight gain Increased blood pressure
Methotrexate
Most common: Nausea and mucosal ulcers
Others: Leukopenia, anemia, stomatitis, GI ulcerations, alopecia and hepatotoxicity
Mycophenolate mofetil
Nausea, dyspepsia, abdominal pain, hepatotoxicity, hematologic toxicity and increased risk of infections
Sirolimus and Everolimus
Hematologic toxicity
Hepatotoxicity
Hypertriacylglycerolemia
HUS
