31 Hypothalamus (Adverse effects)

Question 1

Somatotropin

Answer 1

Children: Pseudotumor cerebri, slipped capital femoral epiphysis, progression of scoliosis, edema, hyperglycemia
Turner syndrome: Otitis media
Adults: Peripheral edema, myalgia, arthralgia and carpal tunnel syndrome

Question 2

Mecasermin

Answer 2

Hypoglycemia, intracranial hypertension, Adenotonsillar hypertrophy, and asymptomatic liver enzyme elevation

Question 3

Octreotide

Answer 3

Nausea, vomiting, abdominal cramps, flatulence, steatorrhea, gallstones, sinus bradycardia and conduction problems, and vitamin B12 deficiency

Question 4

Pegvisomant

Answer 4

May elevate liver enzymes

Question 5

Gonadotropins

Answer 5

Women: Ovarian hyperstimulation syndrome (Acites, hydrothorax, hypovolemia, shock), multiple pregnancies, headache, depression, edema
Men: Gynecomastia

Question 6

GnRH agonists

Answer 6

Hot flashes, depression, decreased libido, vaginal dryness, generalized pain, ovarian cysts and osteoporosis (prolonged treatment)

Question 7

GnRH antagonists

Answer 7

Hypersensitivity and allergic reactions including anaphylaxis

Question 8

Dopamine agonists

Answer 8

Nausea, headache, dizziness, psychiatric manifestations, erythromelalgia
High doses: Pulmonary infiltrate, and valvular heart disease

Question 9

Vasopressin related drugs

Answer 9

Dilutional hyponatremia