43 Antiviral (Adverse effects)

Question 1

Acyclovir

Answer 1

Well tolerated.
GI disturbances, headache, rash
IV: Phlebitis, and reversible renal dysfunction

Question 2

Famciclovir and Valacyclovir

Answer 2

Well tolerated.

GI disturbances, headache, rash

Question 3

Ganciclovir

Answer 3

Leukopenia, thrombocytopenia, retinal detachment, hepatic and renal dysfunction, rash, fever and GI disturbances

Question 4

Cidofovir

Answer 4

Nephrotoxicity, neutropenia, and metabolic acidosis

Question 5

Trifluridine

Answer 5

Superficial ocular irritation and hyperemia

Question 6

Foscarnet

Answer 6

Renal impairment, hematologic toxicity, cardiac arrhythmias and heart failure, seizures, and pancreatitis

Question 7

Nucleoside reverse transcriptase inhibitors (NRTIs)

Answer 7

Lactic acidosis, hepatic steatosis, lipodystrophy

Question 8

NNRTIs

Answer 8

Rashes (can progress to SJS)

Efavirenz->Teratogenic

Question 9

Protease inhibitors

Answer 9

Lipodystrophy, hyperlipidemia, insulin resistance and diabetes, liver dysfunction and hepatitis