42 Fungi

Question 1

Amphotericin B

Answer 1

Renal toxicity (80% of cases), hypokalemia, hypomagnesemia, azotemia, acute liver failure, cardiac arrhythmias, hematologic toxicity, and infusion related effects (chills, fever, headache, nausea, vomiting)

Question 2

Azoles

Answer 2

Systemic adm->Skin rash, hepatotoxicity, hematologic toxicity, GI toxicity
Fluconazole->Birth defects (High doses)
Voriconazole->Visual disturbances

Question 3

Terbinafine

Answer 3

Rarely liver failure (when given orally)

Question 4

Echinocandin drugs

Answer 4

Headache, fever, phlebitis, and abnormal liver functions test

Question 5

Flucytosine

Answer 5

Hematologic toxicity and cardiopulmonary arrest

Question 6

Griseofulvin

Answer 6

Dizziness, headache, insomnia