32 Thyroid (Adverse effects)

Question 1

Levothyroxine

Answer 1

Hyperthyroidism (excess doses)

Cardiotoxicity (High starting dose in elderly)

Question 2

Liothyronine

Answer 2

More cardiac effects than levothyroxine

Question 3

Thioamide drugs

Answer 3

GI-distress, SLE-like syndrome, liver injury and fatal liver failure, agranulocytosis, pruritic maculopapular rash, fever, arthralgia, relapse (especially if thyroid stimulating antibodies), transient leukopenia
(G SLAP FART)
Methimazole–>Fetal damage
PTU–>Increased risk of liver failure

Question 4

Potassium iodide

Answer 4

Skin rashes, salivary gland swelling, sore gums, hypersensitivity reactions, metallic taste and GI discomfort

Question 5

Sodium iodide

Answer 5

Destruction of fetal thyroid tissue