41 Tuberculosis (Adverse effects)

Question 1

Isoniazid

Answer 1

Hepatotoxicity, peripheral neuritis (in B6 deficiency), toxic encephalopathy and seizures, and hematologic toxicity

Question 2

Ethambutol

Answer 2

Dose dependent optic neuritis and impaired red-green colour discrimination, hyperuricemia and gout, hepatitis, and hematologic toxicity

Question 3

Pyrazinamide

Answer 3

Hyperuricemia and gout, hepatitis, hematologic toxicity, arthralgia and increased serum iron concentration

Question 4

Rifampin

Answer 4

Hepatotoxicity, Hypersensitivity (chills, fever, fatigue, headache 50% of patients)
-High doses->Nephrotoxicity, hematologic toxicity and red discoloration of body fluids

Question 5

Rifabutin

Answer 5

GI irritation

Question 6

Bedaquiline

Answer 6

Prolonged QT interval, hepatotoxicity and arthralgia

Question 7

Dapsone

Answer 7

GI disturbances, peripheral neuropathy, optic neuritis and blurred vision, proteinuria, nephrotic syndrome, SLE-like syndrome, hematologic toxicity and hemolytic anemia (in G6PD def.)

Question 8

Clofazimine

Answer 8

GI and hepatotoxicity, photosensitivity, and discoloration of skin and body fluids