6 Cholinergic agonists (Adverse effects)

Question 1

Direct-acting muscarinic agonists

Answer 1

Nausea, vomiting, diarrhea, urinary urgency, salivation, sweating, cutaneous vasodilation, bronchial constriction, and mitosis

Question 2

Direct-acting nicotinic agonists

Answer 2

Acute toxicity->
-Convulsions that may progress to coma and respiratory arrest
-Depolarization blockade and respiratory paralysis
-Hypertension and cardiac arrhythmias
Chronic toxicity->
-Vascular disease and coronary death
-Ulcer recurrence in PUD

Question 3

Cholinesterase inhibitors

Answer 3

Same as Direct-acting muscarinic agonists + CNS involvement (cognitive disturbances, convulsions, and coma) and peripheral effects such as depolarizing neuromuscular blockade

Question 4

Type 5 phosphodiesterase inhibitors

Answer 4

Headache, nasal congestion, dyspepsia, myalgia, back pain, visual disturbances, and reduction of supine blood pressure about 7-8 mm Hg