34 Reproductive (Adverse effects)

Question 1

Estrogens

Answer 1

Breast tenderness, headache, edema, changes in libido, hypertension, thromboembolic diseases, gallbladder disease, and increased risk of breast cancer

Question 2

Synthetic progestins

Answer 2

Increased incidence of acne, Hirsituism, increased libido, and oily skin

Question 3

Estrogen-progestin contraceptives

Answer 3

Combined effects:

• Breast tenderness, headache, edema, changes in libido, hypertension, thromboembolic diseases, gallbladder disease, and increased risk of breast cancer
• Increased incidence of acne, Hirsituism, increased libido, and oily skin

Question 4

Estrogen receptor antagonists

Answer 4

Clomiphene->Multiple births
Tamoxifen->Hot flashes, vaginal bleeding and menstrual irregularities, and increased risk of endometrial cancer
Raloxifene->Hot flashes and increased risk of thromboembolic diseases

Question 5

Estrogen synthesis inhibitors

Answer 5

Hot flashes, vaginal bleeding and menstrual irregularities, back pain

Question 6

Antiprogestins

Answer 6

GI symptoms and heavy uterine bleeding

Question 7

Anabolic steroids

Answer 7

Athletes->Tendon rupture, hepatic dysfunction, increased aggressiveness, acne, decreased testicular size and function, impotence, closing of epiphysis and premature cessation of growth
Women->Masculinization, Hirsituism, deepening of voice and menstrual irregularities

Question 8

Danazol

Answer 8

Increased incidence of acne, Hirsituism, menstrual irregularities, oily skin, hypercholestrolemia, hepatotoxicity, thromboembolic events, and teratogenicity

Question 9

5α-reductase inhibitors

Answer 9

Increased risk of aggressive cancers (but decreased risk of less aggressive ones), decreased libido, erectile dysfunction, and gynecomastia