40 Quinolones and antifolates

Question 1

Sulfonamides

Answer 1

Crystalluria, Skin rashes, Steven-Johnsons syndrome, Gi distress, headache, hepatitis, hematologic toxicity, hemolytic anemia (in G6PD deficiency) and kernicterus in newborns

Question 2

Trimethoprim

Answer 2

GI toxicity, rashes, hepatitis, hematologic toxicity

Question 3

Fluoroquinolones

Answer 3

Neuropathy, abnormal blood glucose, seizures, inhibition of metabolism of caffeine and theophylline, insomnia, photosensitivity, prolonged QT, tendonitis and rupture, anxiety, restlessness and confusion (NASIIPP TARC)

Question 4

Nitrofurantoin

Answer 4

GI irritation, pulmonary fibrosis, hepatitis, and hematologic toxicity

Question 5

Daptomycin

Answer 5

Muscle toxicity

Question 6

Polymyxin B

Answer 6

Nephrotoxicity and neurotoxicity when given parenterally