26 Autacoids (Adverse effects)

Question 1

First generation H1 blockers

Answer 1

Sedation (excitement in children), dry mouth, blurred vision, tachycardia, urinary retention, and hallucination

Question 2

Second generation H1 blockers

Answer 2

Cetirizine->May cause sedation

Astemizole and terfenadine->Prolongation of QT (Torsades de pointes)

Question 3

Intranasal H1 blockers

Answer 3

Dizziness, drowsiness, headache, fatigue, dry mouth, nasal irritation and weight gain

Question 4

Ophthalmic H1 blockers

Answer 4

Transient stinging and burning of the eyes

Question 5

Serotonin agonists

Answer 5

Cisapride->Fatal prolongation of QT
Tegaserod->Increased risk of MI and stroke
Fibanserin->Severe syncope (with alcohol, hepatic dysfunction, and inhibitors of drug metabolism)

Question 6

Prostaglandin E1 derivatives

Answer 6

Alprostadil->Penile pain, penile fibrosis, priapism, flushing, diarrhea, headache and fever
Misoprostol->Diarrhea, abdominal pain, uterine contractions and labour

Question 7

Latanoprost

Answer 7

Permanent eye colour change (by increasing the amount of melanin in melanocytes)