38 Cell wall inhibitors (Adverse effects)

Question 1

Penicillins

Answer 1

• Seizures (high doses), Diarrhea, superinfections (Staph and C. difficile)
• Hypersensitivity reactions->Urticaria, anaphylaxis, serum sickness, interstitial nephritis, hepatitis, and rashes
• Ampicillin->Maculopapular rash

Question 2

Cephalosporins

Answer 2

Hypersensitivity (rare, cross-sensitivity with penicillins)

• Cefotetan->Platelet dysfunction and bleeding
• Cefepime->Drug induced encephalopathy

Question 3

Monobactams

Answer 3

Hypersensitivity (rare, cross-sensitivity with penicillins and cephalosporins)
Thrombophlebitis

Question 4

Carbapenems

Answer 4

Cross-sensitivity with penicillins, seizures in patients with epilepsy, GI and hematologic toxicity

Question 5

Vancomycin

Answer 5

Nephro- and ototoxicity

Hypotension and erythematous rash (called red neck syndrome)

Question 6

Bacitracin

Answer 6

Very nephrotoxic

Question 7

Fosfomycin

Answer 7

Diarrhea