Diagnostiek

Question 1

What are the steps in the diagnostic process?

Answer 1

Pt → order dr → collectie → transport → analyse + labokwaliteitscontrole → data flow → interpretatie dr → diagnose en behandeling

Question 2

What is the first phase of the diagnostic process?

Answer 2

Pre-analytische fase

Question 3

What is included in the pre-analytical phase?

Answer 3

Staal collectie, collectie relevante medische informatie, voorbereiding, transport en bewering van staal tot in labo geraken

Question 4

What is the second phase of the diagnostic process?

Answer 4

Analytische fase

Question 5

What is the third phase of the diagnostic process?

Answer 5

Post-analytische fase

Question 6

What defines Category 1 samples?

Answer 6

Normaal steriel, zoals bloedkweek, CSF, biopsie

Question 7

In Category 1 samples, is the presence of any germ relevant?

Answer 7

Ja

Question 8

What defines Category 2 samples?

Answer 8

Niet aspectisch kunnen afnemen → nooit volledig steriel, zoals urine, respiratoire tractus

Question 9

In Category 2 samples, what is important to note?

Answer 9

Overwegende kiem + hoort bij pathogene klasse

Question 10

What defines Category 3 samples?

Answer 10

Zwaar gekoloniseerd, zoals huid, mucosa, stoelgang, keel

Question 11

In Category 3 samples, is the presence of many germs relevant?

Answer 11

Ja (veel)

Question 12

What is the advantage of microscopy and Gram staining?

Answer 12

Kwaliteitscontrole, snelle diagnostische informatie, onderscheid gram + of -

Question 13

What is a disadvantage of microscopy and Gram staining?

Answer 13

Lage sensitiviteit, lage discriminatie kracht

Question 14

What is a key benefit of bacteriële kweek en identificatie?

Answer 14

Detectie verschillende bacteriën op hetzelfde moment

Question 15

What is a disadvantage of bacteriële kweek?

Answer 15

Sommige zeer traag, zoals TB

Question 16

What is an advantage of virale kweek?

Answer 16

Detectie verschillende virussen, gevoeligheidstesten mogelijk

Question 17

What is a disadvantage of virale kweek?

Answer 17

Soms late diagnose door traag groeiende virussen

Question 18

What is an advantage of antigen tests (including ELISA)?

Answer 18

Snel testresultaat, gemakkelijk om uit te voeren

Question 19

What is a disadvantage of antigen tests?

Answer 19

Sensitiviteit afhankelijk van lading

Question 20

What is a key benefit of moleculaire technieken?

Answer 20

Hoge sensitiviteit en specificiteit

Question 21

What is a disadvantage of moleculaire technieken?

Answer 21

Alleen vinden waarnaar gezocht wordt

Question 22

What is a major advantage of serologie?

Answer 22

Gebruik voor niet-kweekbare micro-organismes

Question 23

What is a disadvantage of serologie?

Answer 23

Specificiteit niet altijd geweldig

Question 24

What is the rationale behind diagnostic stewardship?

Answer 24

Juiste test, voor juiste pt op het juiste tijdstip voor optimale klinische zorg

Question 25

What does post-test probabiliteitscalculatie involve?

Answer 25

In theorie performantie test

Question 26

True or False: Testing should be done on patients with the lowest pre-test probability.

Answer 26

False

Question 27

What is a strategy to improve diagnostic testing?

Answer 27

Restrictie pt met lage pretest probabiliteit

Question 28

What is a disadvantage of combination testing?

Answer 28

Suboptimale sensitiviteit

Question 29

What is a disadvantage of molecular panel-based testing?

Answer 29

Supaoptimale specificiteit

Question 30

What is a key factor for effective diagnostic testing in pneumonia?

Answer 30

Gevoeligheidsbepalling nodig