Deficiencia de GH Flashcards

1
Q

Definição:

A

a

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2
Q

Epidemiologia:

A

Incidência de 1/4.000-1/3.500.

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3
Q

Etiologia:

A

Idiopático, *Adquirido e **Congênito

*Sind. de Sheehan, Tuberculose, Histiocitose X, Tumor hipotalâmico-hipofisário, TCE, Hipofisite linfocitica, Sarcoidose, Hemocromatose, Hipofisectomia e Radioterapia

**Agenesia de corpo caloso e Displasia septo-óptica

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4
Q

Fisiopatologia:

A

Def de GHRH/ +Somatostatina -> def de GH -> -IGF-1 -> +massa gorda, sarcopenia e osteopenia

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5
Q

Quadro Clinico:

A

Fadiga, Humor depressivo, Labilidade emocional, Perda de memoria e Ganho de peso

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6
Q

Exame Físico:

A

Baixa estatura, reducao da velocidade de crescimento

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7
Q

Exames Complementares:

A

GH, *IGF-1, IGFBP-3 e Teste tolerância a insulina, Teste GHRH-arginina e Teste do glucagon

*Se def em 2- hormonios hipofisarios requer teste de estimulo

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8
Q

Diagnostico Diferencial:

A

Insuficiência adrenal, Hipogonadismo e Hipotireoidismo

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9
Q

Tratamento (Medscape, 2015):

A

(-30a)
hGH 0,4-0,5mg/dia SC

(30-60a)
hGH 0,2-0,3mg/dia SC

(+60a)
hGH 0,1-0,2mg/dia SC

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10
Q

Complicações:

A

Doenças cardiovasculares e Dislipidemia

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