Curcumin Flashcards
Turmeric Common Names: t
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Turmeric and Curcumin
Source
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Turmeric – Health Claims
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Turmeric and Curcumin in Foods and Cosmetics
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Turmeric Supplements
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Turmeric Side Effects
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Curcuminoids – Drug Interactions
.
Curcumin
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Curcumin Properties
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Curcumin’s bioavailability can improved by:
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Curcumin – Stability
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Curcumin – Biological Activities
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Curcumin – Mechanism of Action
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Curcumin – Potential Health Benefits
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Curcumin – Dosage Forms
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Curcumin Safety & Recommended Dose
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Curcumin - Side Effects
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inhibit ROS-generating enzymes
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Modulate the activity of GSH, catalase, and SOD enzymes
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Modulates cell-signaling molecules
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stimulates the immune system and LDL.
.
enolic form
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curcumin undergoes degradation
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liposomes, nano-formulations)
.
structural analogs:
dimethylcurcumin, glycosylated curcumin)
.
soluble ethanol, dimethyl sulfoxide (DMSO), acetone)
.
Low solubility, stability issues
.
tamoxifen, paclitaxel)
.
loratadine
.
midazolam, fluoxetine)
.
Aspirin
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Warfarin
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stomach upset (some individuals)
.
Helps Treat Ulcers
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flavoring agent to drinks in Southeast Asia.
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used as a dietary supplement for inflammation, arthritis, stomach, skin, liver, and
gallbladder problems, cancer, and other conditions.
.
Indian saffron
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Curcuma aromatica, Curcuma domestica, Curcuma longa
.
Turmeric, a plant related to———is grown throughout India, other parts of Asia, and
Central America.
L
Historically → used South Asia (4000 years) →
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Today → used as a
.
A ————- and a major ingredient in curry powder.
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Primary active ingredients of turmeric
.
—————is a polyphenol derived from the
herbal remedy and dietary spice turmeric.
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Curcuminoids in turmeric help————— not supported by strong studies.
.
The National Center for Complementary and Integrative Health (NCCIH): studied curcumin for
.
————as an additive: canned beverages, dairy, baked goods, cereals
sauces, and curry powders.
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Butter and cheese
.
Cosmetics and supplements:
.
suppress fat tissue production
.
antiseptic
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scavenge foreign proteins and amyloid plaques
.
prevent the production of diabetes-inducing inflammatory compounds,
.
Vegi-caps .
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Topical creams and ointments
.
With vitamins supplements
.
Drink powders
.
other compounds are combined with turmeric and curcumin for———-
.
Very large doses of curcumin (oral) →
.
Poor bioavailability: due to ———
.
stimulates the immune system and decrease LDL.
.
efficient scavenger of peroxyl radicals
.
Pathological processes of oxidative stress closely related to those of
inflammation (one can be easily induced by another) HOW ?
.
Increase serum alkaline phosphatase and lactate dehydrogenase contents.
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Rash , yellow stool
.
———————are the major mechanism by which
curcumin exerts its health benefits.
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Health benefits are best achieved when curcumin is combined with agents such
as———
.
