CREATINE Flashcards
endogenous amino acid derivative found largely in muscle cells and synthesized by us
L
nitrogen-containing ….. derivative with ….. and ….. groups attached Due to intramolecular cyclisation to creatinine
.
creatine is not ….. in aqueous solution.
L
is formed when a portion of total creatine binds to
phosphate in the muscles.
K
..... catalyzes the process, which produces phosphocreatine (PCr).
O
Phosphocreatine binds to adenosine
diphosphate and converts it to ATP (adenosine triphosphate), a crucial cellular
energy source for short-term …… demands before oxidative phosphorylation.
.
Sources
H
made in our body 1 gram per day by the liver pancreas and the kidneys
K
Muscle mass and strength.
K
Increase Lean body mass
H
Increase the endurance and strength
G
It shows a excellent effect for the people in rehabilitation programs
K
If its taken by postmenopoasul women it increase the strength and bone density
J
Lows weight and maintain muscle
G
retain muscle mass
K
stimulate fat reduction
O
control adult-onset obesity.
I
Diabetes
N
reduce GLUT-4 transporter reductions during
immobility while also raising GLUT4- after atrophy restoration
J
control blood glucose and reduce HBA1c and increase
insulin sensitivity
H
Treatment for some conditions
J
improve both muscular dystrophies and idiopathic inflammatory
myopathy if the patient took creatine supplement
J
Skin
R
Antioxidants
F
Anti wrinkles
F
Help in hydration of the skin
F
Cognitive Function
N
raise PCr content in the brain and hence improve
brain function
J
boosted oxygen consumption in the brain and decreased mental tiredness in those who did
repetitive mathematical computations.
J
enhanced working memory and
processing speed
;
Improve the sleep
E
Heart diseases
H
can protect the heart form ischemic attacks
O
Decrease incidence of arrhythmia
K
Improve myocardial function
L
Showed some benefit in heart failure patient
O
Immune
L
decreasing pro inflammatory cytokines
O
reducing pulmonary and systemic consequences of lung ischemia
L
Dosage forms and recommended doses
L
Dosage regimens in clinical trials vary from 2 to 20 g daily and from a week up to 3 years
J
There is another dosing method the loading method in which the patient take 5 g 4 time a day for
10
I
Side-effects (adverse drug reactions) and contraindications.
I
there is a study concluded that creatine may may promote metastasis of some cancers [
;
should be avoided in renal insufficiency because it might build up in the body.
L
