Comp Med No. 2 2012 Flashcards
Which human disease does Fmr 1- knockout mice model?
a. Autism
b. Down’s syndrome
c. Fragile X Syndrome
d. Alzheimer’s Disease
c. Fragile X Syndrome
Where in the adrenal gland is corticosterone produced?
a. Zona fasicularis of the cortex
b. Zona glomerulosa of the medulla
c. Zona reticularis of the cortex
d. Zona fasicularis of the medulla
a. Zona fasicularis of the cortex
In a 7am-7pm light cycle, when would you expect to see the highest spike in fecal corticosterone concentration in a non-human primate?
a. 4 am
b. 4 pm
c. 10 am
d. 10 pm
a. 4 am
BMTR mice are animal models of what human disease?
Autism
What the hell is Peromyscus poliontus trissyllepsis?
Perdido Key Beach Mouse
What cell line do epitheliotropic lymphomas usually arise from?
a. B cell
b. T cell
c. Both B and T cell
b. T cell
Which of the following neoplasms are more common in the Perdido Key beach mouse?
a. Squamous cell carcinoma
b. Mammary adenocarcinoma
c. Melanoma
d. Cutaneous B cell lymphoma
d. This is currently the ONLY reported neoplasm in this species.
With regard to histopathologic analysis, what is the term used to describe a lymphocyte infiltration that extends into overlying epidermis where it forms discrete aggregates surround by a clear halo?
a. Pautrier microabscess
b. Splendore-hoeppli reaction
c. Angel effect
d. Wallerian degeneration
a. Pautrier microabscess
HeLa cells or HT29 cells in 0.1 mL culture media were inoculated subcutaneously on the flank immediately caudal to the right axilla in female (HeLa) or male (HT29) mice, respectively, and the tumors grew as solid masses. These are examples of:
a. Autografts
b. Xenografts
c. Allografts
d. Isografts
b. Xenografts
What kind of animal is a Hsd:RH-Foxn1rnu?
Athymic, nude rat
What is the scientific name for the laboratory Guinea Pig?
Cavia porcellus
What does NAFLD stand for?
Nonalcoholic fatty liver disease
What feature makes the guinea pig a good model for the study of NAFLD?
Guinea pigs transport cholesterol within LDL, a unique characteristic resembling human lipid and lipoprotein interaction.
A decrease in the _____________ of the ischemic heart is an early sign of heart failure.
Ejection fraction
What is unique about the rabbit’s tricuspid valve?
The tricuspid valve of the rabbit has only two cusps, rather than three in many other mammals.
In rabbits, what artery can be occluded to induce myocardial infarction?
Left circumflex coronary artery
The most commonly used intravenous contrast agents used in MRI are based on chelates of what chemical element?
gadolinium
What is the most commonly reported site of osteosarcoma development in the rabbit?
a. Appendicular skeleton, forelimb
b. Appendicular skeleton, hind limb
c. Skull
d. Spine
c. Skull
What is the most common site of osteosarcoma metastasis in rabbits?
a. Subcutis
b. Liver
d. CNS
c. Lung
What sign of osteosarcoma formation in dogs is most likely to be similar in the rabbit?
a. Painful swelling and lameness in the forelimbs
b. Elevated ALP
c. Radiographic evidence of pulmonary metastasis
d. Increased body mass as a predisposing factor
c. Radiographic evidence of pulmonary metastasis
What is the most common tumor in rabbits?
Uterine AC
T or F. The normal coronary anatomy of pigs and humans includes three primary arteries that arise from two of the three sinuses above the semilunar cups of the aorta, known as sinuses of Valsalva.
True
T or F. The RCA arises from the right sinus of Valsalva and travels between the right auricle and pulmonary trunk on its way to the coronary groove.
True
Regarding coronary anomalies, what clinical signs can potentially result from such anomalies?
These anomalies can lead to chest pain, arrhythmias, myocardial infarction and heart failure.
T or F: spontaneous heart disease and sudden cardiac health death are well-documented conditions in adult and geriatric chimpanzees and are the leading cause of death in this species
True
T or F: The conditions used to define Metabolic Syndrome in humans are different from the conditions used to define metabolic syndrome in chimpanzees.
False: The same conditions are used in humans and chimpanzees: overweight, fasting hyperglycemia, low HDL, hypertryglyceridemia or hypercholesterolemia, and systemic hypertension
T or F: a thorough semiannual physical exam is recommended for the geriatric chimpanzee population, with monthly health checks and monitoring of response to therapy
True
T or F: systemic hypertension, a component of metabolic syndrome, can be reduced with weight loss and further managed with use of enalapril or amlodipine
True
What is measured in humans to indicate iron stores?
Serum ferritin
What does the hemogram profile look like in humans with uncomplicated Iron-deficiency anemia?
Microcytic, hypochromic regenerative anemia
What is hepcidin?
A principal regulator of systemic iron homeostasis
What is dual energy X-ray absorptivity used to measure?
bone mineral density
True/False. There are 40 chromosomes present in macaques
False - 42
Osteochondromas in cats is often associated with what virus:
a. Feline panleukopenia
b. Feline herpes virus
c. Feline leukemia virus
d. Feline calicivirus
c. Feline leukemia virus
A 6.5 year old rhesus macaque with multiple cartilage-capped bony masses projecting from long bones is consistent with what diagnosis?
a. Osteochondroma
b. Osteosarcoma
c. Fungal granuloma
d. Normal finding in growing macaque
a. Osteochondroma
A single cartilage-capped bony projection that arises on the external surface of bone containing a marrow cavity that is continuous with that of underlying bone describes what lesion?
Osteochondroma
